"Fundamentals of Tissue Engineering and Regenerative Medicine" provides a complete overview of the state of the art in tissue engineering and regenerative medicine. Tissue engineering has grown tremendously during the past decade. Advances in genetic medicine and stem cell technology have significantly improved the potential to influence cell and tissue performance, and have recently expanded the field towards regenerative medicine. In recent years a number of approaches have been used routinely in daily clinical practice, others have been introduced in clinical studies, and multitudes are in the preclinical testing phase. Because of these developments, there is a need to provide comprehensive and detailed information for researchers and clinicians on this rapidly expanding field.

This book offers, in a single volume, the prerequisites of a comprehensive understanding of tissue engineering and regenerative medicine. The book is conceptualized according to a didactic approach (general aspects: social, economic, and ethical considerations; basic biological aspects of regenerative medicine: stem cell medicine, biomolecules, genetic engineering; classic methods of tissue engineering: cell, tissue, organ culture; biotechnological issues: scaffolds; bioreactors, laboratory work; and an extended medical discipline oriented approach: review of clinical use in the various medical specialties). The content of the book, written in 68 chapters by the world's leading research and clinical specialists in their discipline, represents therefore the recent intellect, experience, and state of this bio-medical field.

General Aspects: General and Ethical Aspects

The History of Tissue Engineering and Regenerative Medicine in Perspective
Economic Modeling and Decision Making in the Development and Clinical Application of Tissue Engineering
Ethical Issues in Tissue Engineering
Sourcing Human Embryonic Tissue: The Ethical Issues
Tissue Engineering and Regenerative Medicine. Their Goals, Their Methods and Their Consequences from an Ethical Viewpoint
Biological Considerations: Tissue and Organ Differentiation
Control of Organogenesis: Towards Effective Tissue Engineering
Cytokine Signaling in Tissue Engineering
Influence of Mechanical Effects on Cells. Biophysical Basis
Engineering Strategies: Engineering at the Genetic and Molecular Level
Towards Genetically Designed Tissues for Regenerative Medicine
Posttranscriptional Gene Silencing
Biomolecule Use in Tissue Engineering
Engineering Strategies: Engineering at the Cellular Level
Fetal Tissue Engineering: Regenerative Capacity of Fetal Stem Cells
Embryonic Stem Cell Use
The Unrestricted Somatic Stem Cell (USSC) From Cord Blood For Regenerative Medicine
Mesenchymal Stem Cells: New Insights Into Tissue Engineering and Regenerative Medicine
Stem Cell Plasticity: Validation Versus Valedictory
Engineering Strategies: Engineering at the Tissue Level
Bone Tissue Engineering
Cartilage Engineering
Muscle Tissue Engineering
Tendon and Ligament Tissue Engineering: Restoring Tendon/Ligament and Its Interfaces
Neural Tissue Engineering and Regenerative Medicine
Adipose Tissue Engineering
Intervertebral Disc Regeneration
Tissue Engineering of Ligaments and Tendons
Tissue Engineering of Cultured Skin Substitutes
Dental Hard Tissue Engineering
Mucosa Tissue Engineering
Tissue Engineering of Heart Valves
Engineering Strategies: Engineering at the Organ Level
Breast Tissue Engineering
Bioartificial Liver
Pancreas Engineering
Tissue-Engineered Urinary Bladder
Cell-Based Regenerative Medicine for Heart Disease
Technical Aspects: Biomaterial Related Aspects
Biomaterials
Biomaterial-Related Approaches: Surface Structuring
Mineralised Collagen as Biomaterial and Matrix for Bone Tissue Engineering
Hydrogels for Tissue Engineering
Technical Aspects: Scaffold Related Aspects
Defining Design Targets for Tissue Engineering Scaffolds
Scaffold Structure and Fabrication
Prospects of Micromass Culture Technology in Tissue Engineering
Technical Aspects: Laboratory Aspects and Bioreactor Use
Laboratory Procedures - Culture of Cells and Tissues
Bioreactors in Tissue Engineering: From Basic Research to Automated Product Manufacturing
The Evolution of Cell Printing
Biophysical Stimulation of Cells and Tissues in Bioreactors
Microenvironmental Determinants of Stem Cell Fate
Transplantation Issues: Functional Aspects in Biological Engineering
Perfusion Effects and Hydrodynamics
Ex Vivo Formation of Blood Vessels
Biomechanical Function in Regenerative Medicine
Influence of Biomechanical Loads
Transplantation Issues: Immune System Issues
Innate and Adaptive Immune Responses in Tissue Engineering
Toll-Like Receptors: Potential Targets for Therapeutic Interventions
Transplantation Issues: Study Design Principles
Tissue Engineered Models for In Vitro Studies
In Vivo Animal Models in Tissue Engineering
Assessment of Tissue Responses to Tissue-Engineered Devices
Clinical Use: Clinical Application
Evidence-based Application in Tissue Engineering and Regenerative Medicine
Tissue Engineering Applications inNeurology
Tissue Engineering in Maxillofacial Surgery
Tissue Engineering Strategies in Dental Implantology
Tissue Engineering Application in General Surgery
Regeneration of Renal Tissues
Tissue Engineering Applications in Plastic Surgery
Tissue Engineering Applications for Cardiovascular Substitutes
Tissue Engineering Applications in Orthopedic Surgery
Tissue Engineering and Its Applications in Dentistry
Tissue Engineering Applications in Endocrinology
Regenerative Medicine Applications in Hematology
The Reconstructed Human Epidermis Models in Fundamental Research
Clinical Use: Clinical Handling and Regulatory Issues
Regulatory Issues.