The articles in this volume cover the various radiosurgical techniques used to treat benign and malignant intracranial tumors, cavernous malformations, and functional disorders, as well as a wide array of specific details on medical physics, neuroimaging, and anesthetic support. Particular emphasis is put on the optimal combination of microneurosurgery and radiosurgery for attaining the best functional results in patients with vestibular schwannomas, craniopharyngiomas, and pituitary adenomas, and on the most effective methods of treatment planning and radiation dosimetry in cases of metastatic brain tumors. The highlighted clinical aspects include indications for radiosurgery and the prediction of patients' prognosis, along with analysis of outcomes in comparison with results achieved by other modalities in the context of multifaceted therapeutic strategies. In addition, possible options for applying advanced treatment using such modern devices as Leksell Gamma Knife Perfexion^TM and Icon^TM are presented in depth. This information will interest both radiosurgical practitioners and neurosurgeons, and help them to provide optimal care and to achieve the greatest benefit of their patients. This book will serve as an excellent companion for the previous publication 'Gamma Knife Neurosurgery in the Management of Intracranial Disorders' (Acta Neurochirurgica Supplement, Volume 116, Springer, 2013).

Dr. Mikhail Chernov completed his medical education (The First Leningrad Pavlov Medical University, 1989) and neurosurgical training (Russian Polenov Neurosurgical Institute, 1995) in St. Petersburg, Russia. In 2000 he became a clinical and research fellow in the Department of Neurosurgery of the Tokyo Women's Medical University, and in 2006 obtained a Doctor of Medical Sciences degree and became assistant professor in the Faculty of Advanced Techno-Surgery of the same institution. He has written over 140 scientific papers, served as editor-in-chief of several books, including Acta Neurochirurgica Supplement Volume 116 'Gamma Knife Neurosurgery in the Management of Intracranial Gliomas' (Springer, 2013), and as Executive Director of the Asian Gamma Knife Academy, member of the WFNS Radiosurgery Sub-Committee, ex officio board member of the International Stereotactic Radiosurgery Society, and chairman of its Education Committee.

Dr. Motohiro Hayashi graduated from the School of Medicine, Gunma University in 1991. Thereafter, he started neurosurgical training in the Department of Neurosurgery of the Tokyo Women's Medical University (TWMU). Between 1999 and 2001, he visited Timone University Hospital (Marseille, France), obtained the official French neurosurgical diploma (D'AFSA de Neurochirurgie), and completed training in stereotactic radiosurgery. In 2002, he returned to the same department of TWMU, and has become clinical and research assistant professor (2006), and subsequently assistant professor and director of the Gamma Knife Unit. His experience includes >10,600 cases of Gamma Knife surgery. He has published over 200 papers on stereotactic radiosurgery, and given over 350 conference presentations. He is the founder of the Asian Gamma Knife Training Program (currently, Asian Gamma Knife Academy), and has also been a member of the WFNS Radiosurgery Sub-Committee, former board member of the International Stereotactic Radiosurgery Society (ISRS), and president of the 12th ISRS Congress held in Yokohama, Japan.

Dr. Clark C. Chen completed his neurosurgery training at the Massachusetts General Hospital in 2008. He pursued clinical fellowships in radiosurgery and stereotactic neurosurgery before becoming the Director of Surgical Neuro-Oncology at the Beth Israel Deaconess Medical Center and assistant professor at the Harvard Medical School. In 2011, he moved to the Department of Neurosurgery, University of California-San Diego, where he rose to the rank of Professor and served as vice-chair of academic affairs. Since 2017, Dr. Chen has held the Lyle French Chair in Neurosurgery at the University of Minnesota. He specializes in treating brain cancers, with focus on minimally invasive surgery. Dr. Chen is an NIH-funded investigator active in national and international neurosurgery as a member of the Executive Committee of the American Association of Neurological Surgeons and of the Joint Tumor Section. He is an editor and reviewer for 20 journals that span the fields of radiosurgery, neurosurgery, clinical medicine, and laboratory research.

Dr. Ian E. McCutcheon received his MD from McGill in 1984. He trained in neurosurgery at the Montreal Neurological Institute and pursued a medical staff fellowship at the NIH (1987-1989). In 1991 he joined the Department of Neurosurgery at the University of Texas M D Anderson Cancer Center, where he remains today as professor of neurosurgery and holds a prestigious Ashbel Smith professorship. His research has focused on the biology of meningiomas and malignant peripheral nerve sheath tumors, and he maintains a parallel interest in neurofibromatosis, von Hippel-Lindau disease, and tumors of the brain and spinal cord. He has published widely (170 papers, 35 book chapters) on neurosurgical oncology, has edited four books, and serves on editorial boards including the Journal of Neuro-Oncology, Neuro-Oncology, World Neurosurgery, and Endocrine Pathology. Dr. McCutcheon is a fellow of the Royal College of Surgeons of Canada and of the American College of Surgeons. He is Vice-President of the Society of University Neurosurgeons and an elected member of the American Academy of Neurological Surgery.