Genetics of the Mouse
Genetics of the Mouse
This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits.
The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided.
In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.
Origins of the Laboratory Mouse
Basic Concepts of Reproductive Biology And GeneticsCytogenetics
Gene Mapping
The Mouse Genome
Epigenetic Control of Genome Expression
Mutations and Experimental Mutagenesis
Transgenesis and Transgenic Animals
The Different Categories of Genetically Standardized Populations of Laboratory Mice
Quantitative Traits and Quantitative Genetics.
Guénet, Jean Louis
Benavides, Fernando
Panthier, Jean-Jacques
Montagutelli, Xavier
| ISBN | 978-3-662-51016-2 |
|---|---|
| Artikelnummer | 9783662510162 |
| Medientyp | Buch |
| Auflage | Softcover reprint of the original 1st ed. 2015 |
| Copyrightjahr | 2016 |
| Verlag | Springer, Berlin |
| Umfang | XVII, 408 Seiten |
| Abbildungen | XVII, 408 p. 106 illus., 44 illus. in color. |
| Sprache | Englisch |
