This is the first book to give a full overview on genome integrity in different species. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. Written by an international panel of experts, the book addresses the connection between genome integrity and human disease.

Replication. Chromosomal DNA Replication: On Replicases, Replisomes, and Bidirectional Replication Factories. Progress Towards the Anatomy of the Eukaryotic DNA Replication Fork. DNA Polymerases and Diseases

Replicative Double-Strand Break Repair. Facing Stalled Replication Forks: The Intricacies of Doing the Right Thing. Germline Double-Strand Break Repair and Gene Targeting in Drosophila: a Trajectory System throughout Evolution
Facets of Double-Strand Break Repair. Structure and Function of Rad50/SMC Protein Complexes in Chromosome Biology. Mechanisms of Non-Homologous DNA End Joining: Aspects of In Vitro Assays. Role of p53 in Double-Strand Break Repair. The Role of Chromatin Structure and Nuclear Architecture in the Cellular Response to DNA Double Strand Breaks
DNA Repair and Pleiotropic Interactions. DNA Base Damage Recognition and Processing. Inter- and Supramolecular Interactions of Protein Kinase CK2 and their Relevance for Genome Integrity. Role of Human Topoisomerase I in DNA Repair and Apoptosis. Genomic Instability in Fanconi Anaemia and Nijmegen Breakage Syndrome
Radiation and other Genotoxic Stress. Induction of DNA Repair Genes in Mammalian Cells in Response to Genotoxic Stress. Pathways of DNA Double-Strand Break Repair in Mammalian Cells after Ionizing Radiation. Genomic Instability: Signaling Pathways Orchestrating the Responses to Ionizing Radiation and Cisplatin. Ion Irradiation as a Tool to Reveal the Spatiotemporal Dynamics of DNA Damage Response Processes.