Understanding the biological role of the diverse oligosaccharides of glycoproteins and glycolipids has been a major challenge in cell biology. Glycosylation is an essential step during molecular recognition and is involved in protein folding, sorting, targeting and intracellular translocation. Further, glycoproteins of the cell membrane play a major role in cell adhesion, hormone function, antibody action and signal mediation. Current knowledge of the molecular and cellular mechanisms involved in these processes is presented.

Components and Mechanisms Involved in Protein Translocation Through the ER Membrane

Protein Sorting Signals for Maintaining Transmembrane Proteins in the Endoplasmic Reticulum
Protein Retention in the Golgi Stack
Signal-Mediated Targeting of Lysosomal Membrane Glycoproteins
VIP21, Caveolae and Sorting in the Trans-Golgi Network of Epithelial Cells
Biogenesis of Neurosecretory Vesicles
Lipid Transport from the Golgi Complex to the Plasma Membrane of Epithelial Cells
Topology and Regulation of Ganglioside Metabolism - Function and Pathobiochemistry of Sphingolipid Activator Proteins
Why Does Baker's Yeast Glycosylate Proteins?
Glycosylation of Nuclear and Cytoplasmic Proteins Is as Abundant and as Dynamic as Phosphorylation
Novel N-Glycosylation in Eukaryotes: Laminin Contains the Linkage Unit ?-Glucosylasparagine
Reprocessing of Membrane Glycoproteins
Mutational Analysis of Carbohydrate and Phospholipid Modifications of a Cell Adhesion Protein
Towards Understanding Roles of Oligosaccharides as Recognition Structures
The Biologic Significance of Glycoprotein Hormone Oligosaccharides
Biosynthesis of Antibodies and Molecular Chaperones
Function of Molecular Chaperones in Protein Folding.