Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C-S coupling.
Probing Gold: X-ray Absorption Spectroscopy
Probing Cells: Cytotoxicity Evaluation
Au(III) series with <i>k</i><sup>2</sup>C,N and <i>k</i><sup>2</sup>N,N' ligands
"Dual Probe" X-ray Absorption Spectroscopy.</p>
<p>Au(I)-phosphine series design
Probing the Protein: Ion Mobility SpectrometryProbing Gold: X-ray Absorption Spectroscopy
Probing Cells: Cytotoxicity Evaluation
Au(III) series with <i>k</i><sup>2</sup>C,N and <i>k</i><sup>2</sup>N,N' ligands
"Dual Probe" X-ray Absorption Spectroscopy.</p>
Ferraz de Paiva, Raphael Enoque
ISBN | 978-3-030-13150-0 |
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Artikelnummer | 9783030131500 |
Medientyp | Buch |
Auflage | Softcover reprint of the original 1st ed. 2018 |
Copyrightjahr | 2019 |
Verlag | Springer, Berlin |
Umfang | XXXIX, 151 Seiten |
Abbildungen | XXXIX, 151 p. 100 illus., 38 illus. in color. |
Sprache | Englisch |