This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.

1. Quality in Non-GxP Research Environment

2. Guidelines & Initiatives for Good Research Practice
3. Learning from principles of evidence-based medicine to optimize nonclinical research practices
4. General Principles of Preclinical Study Design
5. Resolving the tension between exploration and confirmation in preclinical biomedical research
6. Blinding and Randomization
7. Out of control?  Managing baseline variability in experimental studies with control groups
8. Quality of Research Tools
9. Genetic background and sex: impact on generalizability of research findings in pharmacology studies
10. Building robustness intro translational research
11. Minimum information and quality standards for conducting, reporting, and organizing in vitro research
12. Minimum Information in In Vivo Research
13. A reckless guide to P-values: Local evidence, global errors
14. Electronic Lab Notebooks and Experimental Design Assistants
15. Data storage
16. Design of meta-analysis studies
17. Publishers' responsibilities in promoting data quality and reproducibility
18. Quality governance in biomedical research
19. Good Research Practice - Lessons from Animal Care & Use
20. Research collaborations and quality in research: foes or friends?
21. Costs of implementing quality in research practice.