The group B coxsackieviruses have a long and colorful history, dating to the early days of virology as we now know it. In the late 1940s, ultracentrifugation and electron microscopy were new, high-tech tools and suckling mice were suppla- ing monkeys as the virus isolation vessel of choice. Viruses were, often as not, still referred to as "filterable agents. " The rampage of paralytic poliomyelitis epid- ics in the previous 20 or so years had spurred national investment in infectious disease research, resulting in an unprecedented period of virus discovery, eclipsed only a few years later once cell culture became the preferred method to isolate and identify mammalian viruses. The coxsackieviruses were isolated from feces of patients with paralytic poliomyelitis and nonparalytic poliomyelitis (aseptic meningitis), causing disease in suckling mice, but not in adult mice or monkeys. They were considered to be related to the polioviruses on the basis of their physical properties, such as virion size, acid and ether resistance, and temperature stability in 50% glycerol, and were classified into groups A and B by the nature of the disease induced in mice: flaccid paralysis by group A viruses and spastic paralysis by those of group B. Our knowledge of the group B coxsackieviruses has progressed dramatically in the past 60 years.

CVB Genetics

Coxsackieviruses and Quasispecies Theory: Evolution of Enteroviruses
Comparative Genomics of the Coxsackie B Viruses and Related Enteroviruses
Group B Coxsackievirus Virulence
CVB Entry and Replication
The Coxsackievirus and Adenovirus Receptor
Coxsackievirus B RNA Replication: Lessons from Poliovirus
CVB Translation: Lessons from the Polioviruses
Preferential Coxsackievirus Replication in Proliferating/Activated Cells: Implications for Virus Tropism, Persistence, and Pathogenesis
Host-Virus Interaction
The Impact of CVB3 Infection on Host Cell Biology
Host Immune Responses to Coxsackievirus B3
Pediatric Group B Coxsackievirus Infections
CVB-Induced Pancreatitis and Alterations in Gene Expression
The CVB and Etiology of Type 1 Diabetes
Persistent Coxsackievirus Infection: Enterovirus Persistence in Chronic Myocarditis and Dilated Cardiomyopathy
Autoimmunity in Coxsackievirus Infection
CVB Infection and Mechanisms of Viral Cardiomyopathy.