This textbook introduces readers to the scientific basics of cardiovascular medicine and biology. It covers not only developmental but also cellular and molecular aspects of normally functioning vasculature and the heart; importantly, it also addresses the mechanisms leading to and involved in specific cardiovascular diseases. Though the main emphasis is on novel therapies and potential therapeutic targets, specific controversial topics like cardiac remodeling and regenerative capacities are also addressed.

All chapters were written by lecturers from the Imperial College London, in collaboration with their students from the College's BSc Programme in Medical Sciences with Cardiovascular Science. Bridging the gap between clinics and basic biology, the book offers a valuable guide for medical students, and for Master and PhD students in Cardiovascular Biomedicine.

<p>Anatomy of the Heart and Coronary Vasculature

Early Mechanisms of Cardiac Development
Later Mechanisms of Cardiac Development.-  Myocardial Microstructure and Contractile Apparatus
An Introduction to the Cardiac Action Potentials
Cardiac Excitation-Contraction Coupling
Conduction in Normal and Diseased Myocardium
Cell-Based Tachyarrhythmias and Bradyarrhythmias
The Scientific Rationale of Artificial Pacing
Cardiac Contractility
The Scientific Basis of Heart Failure
Molecular and Cellular Basis of Cardiomyopathies
Substrate Remodelling Changes in Heart Failure
Developments in Heart Failure: Mechanical Unloading with LVADs, Exosomes, and MicroRNAs
Pharmacological Targets of Hypertension
The Coagulation Cascade and its Therapeutic Modulation
Cellular and Molecular Mechanisms of Atherosclerosis
Molecular and Cellular Mechanisms of Angiogenesis
Endothelial Function in Normal and Diseased Vessels.</p>