During the last years the heat shock response has been stu-
died as a model system to analyze control mechanisms regula-
ting the synthesis of heat shock proteins providing impor-
tant general insight into the regulation of gene expression.
But the major revelation, which has sparked interest from
all quarters of biology, is the discovery that heat shock
proteins play major roles in an extraordinary variety of
normal cellular processes. They are the focus of investiga-
tions in many areas of cell biology, including protein traf-
ficking, signal transduction, DNS replication, transcrip-
tion, protein synthesis, and in the assembly of di- verse
protein structures. These aspects are thoroughly trea- ted
in the book, as are the implications in immunology, in- fec-
tious diseases, chronic degeneration, hyperthermia, and can-
cer research.

Analysis of Heat Shock Regulation

Transcriptional Activation of Drosophila Heat Shock Genes
Structure and Function of Drosophila Heat Shock Factor
In vivo and in vitro Studies on the Activation and Binding of Human Heat-shock Transcription Factor
Mechanisms of Regulation of Small Heat Shock Protein Genes in Drosophila
Heat Shock Protein Functions in E. coli and Yeast
The Biological Role of the Universally Conserved E. coli Heat Shock Proteins
E. coli Mutants Lacking the dnaK Heat Shock Gene: Identification of Cellular Defects and Analysis of Suppressor Mutations
DnaJ and DnaK Heat Shock Proteins Activate Sequence Specific DNA Binding by RepA
HSP70 Family of Proteins of the Yeast S. cerevisiae
Ubiquitin-Conjugating Enzymes Mediate Essential Functions of the Stress Response
Analysis of Heat Shock Protein Functions
Early Effects of Heat Shock on Enzymes: Heat Denaturation of Reporter Proteins and Activation of a Protein Kinase which Phosphorylates the C-Terminal Domain of RNA Polymerase II
Interaction of HSP47 with Newly Synthesized Procollagen, and Regulation of HSP Expression
In vitro Inhibition of Nascent Polypeptide Formation by HSP70 Proteins
HSP90, a Carrier of Key Proteins that Regulates Cell Function
Genetic Analysis of Heat Shock Protein Functions in Yeast
The Stress Response in the Freshwater Polyp Hydra
Heat Shock Response during Morphogenesis in the Dimorphic Pathogenic Fungus Histoplasma capsulatum
Effects of Heat Shock on Development and Actin mRNA Stability in Drosophila
Heat Shock Proteins and Translocations
Role of HSP60 in Folding/Assembly of Mitochondrial Proteins
Role of Heat Shock Proteins in Mitochondrial Protein Import
A Role for the 73-kDa Heat Shock Cognate Protein in a Lysosomal Pathway of Intracellular Protein Degradation
Immunology
Immune Recognition of Stress Proteins in Infection and in Surveillance of Stressed Cells
Heat Shock Proteins and Mycobacterial Infection
Heat Shock Proteins and Antimicrobial Immunity
Heat Shock Proteins and Antigen Processing and Presentation
Recognition of Heterologous and Autologous Stress Protein Sequences by Heat Shock Reactive ??T Lymphocytes
Expression of Stress Proteins on the Surface of Cells of the Immune System
Medical Applications of Heat Shock Response
Quantification of Protein Denaturation with Sulfhydryl Agents: Application to Heat Shock in Mammalian Cells
Stable Expression of Human HSP70 Gene in Rodent Cells Confers Thermal Resistance
The Role of HSP90 in Tumor Specific Immunity
Heat Shock and Oxidative Injury in Human Cells
Induction of HSP70 Genes in the Mammalian Nervous System by Hyperthermia, Tissue Injury and Other Traumatic Events
Ubiquitin and the Lysosomal System: Molecular Pathological and Experimental Findings.