Better therapy of acute leukemias depends ultimately on better understanding of the distinction between leukemic and normal progenitor cells. Thus, several chapters in this volume describe current knowledge of acute leukemia biology and discuss new classification systems that have arisen consequent to emerging insights into pathogenesis. Treatment has also improved for particular types of acute leukemia. Given our intention that the book be useful to clinicians, we pay particular attention to these advances, to management of acute leukemia in general, and to development of new therapies.

Acute Myeloid Leukemia

Therapy of AML
Diagnosis and Classification of the Acute Myeloid Leukemias (with Discussion of the Role of the Myelodysplastic Syndromes in AML Pathogenesis)
Acute Myeloid Leukemia: Epidemiology and Etiology
Relapsed and Refractory Acute Myeloid Leukemia
Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia: Epidemiology and Etiology
Molecular Biology and Genetics
Acute Lymphoblastic Leukemia: Clinical Presentation, Diagnosis, and Classification
Diagnosis of Acute Lymphoblastic Leukemia
General Approach to the Therapy of Adult Acute Lymphoblastic Leukemia
Recent Clinical Trials in Acute Lymphoblastic Leukemia by the Cancer and Leukemia Group B
Conventional Therapy in Adult Acute Lymphoblastic Leukemia: Review of the LALA Program
ALL Therapy: Review of the MD Anderson Program
Treatment of Adult ALL According to Protocols of the German Multicenter Study Group for Adult ALL (GMALL)
Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
Burkitt's Acute Lymphoblastic Leukemia (L3ALL) in Adults
Treatment of Lymphoblastic Lymphoma in Adults
The Role of Allogeneic Stem Cell Transplantation in the Therapy of Adult Acute Lymphoblastic Leukemia (ALL)
The Role of Autologous Stem Cell Transplantation in the Management of Acute Lymphoblastic Leukemia in Adults
Novel Therapies in Acute Lymphoblastic Leukemia
Minimal Residual Disease Studies in Acute Lymphoblastic Leukemia
Central Nervous System Involvement in Adult Acute Lymphocytic Leukemia
Relapsed Acute Lymphoblastic Leukemia
Emergencies in Acute Lymphoblastic Leukemia
Erratum
Erratum.