Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models and then concentrates on the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses against HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and their implementation into present and future daily clinical practice are highlighted.

The Origin of Hepatitis C Virus

Cell Culture Systems for Hepatitis C Virus
Animal Models for Hepatitis C
Hepatitis C Virus Entry
Hepatitis C Virus Proteins: From Structure to Function
Hepatitis C Virus RNA Translation
Hepatitis C Virus RNA Replication
Virion Assembly and Release
Innate Immune Responses to Hepatitis C Virus
Adaptive Immune Responses in Hepatitis C Virus Infection
Liver Injury and Disease Pathogenesis in Chronic Hepatitis C
Hepatitis C Virus-Specific Directly Acting Antiviral Drugs
Treatment of Chronic Hepatitis C: Current and Future.