Hepatitis delta virus which causes severe acute and chronic liver disease was discovered following the detection of a novel antigen-antibody system in hepatitis B virus carriers. Currently, HDV is classified as a subviral satellite of hepatitis B virus. However, unlike other satellite viruses, the dependenceof HDV on HBV is limited solely to the provision of an envelope of hepatitis B surface antigen for virus assembly. Research into the molecular virology of the HDV life cycle has revealed a fascinating collection of biology. These insights are now beginning to be translated into new potential treatment strategies. There are currently still an estimated 15 million HDV carriers worldwide.
1;Preface;5 2;List of Contents;8 3;List of Contributors;9 4;Structure and Replication of Hepatitis Delta Virus RNA;10 5;HDV RNA Replication: Ancient Relic or Primer?;34 6;HDV Ribozymes;56 7;RNA Editing in Hepatitis Delta Virus;76 8;Post-translational Modification of Delta Antigen of Hepatitis D Virus;100 9;The Role of the HBV Envelope Proteins in the HDV Replication Cycle;122 10;Prenylation of HDAg and Antiviral Drug Development;142 11;Hepatitis Delta Virus Genetic Variability: From Genotypes I, II, III to Eight Major Clades?;160 12;Functional and Clinical Significance of Hepatitis D Virus Genotype II Infection;182 13;Immunology of HDV Infection;196 14;The Woodchuck Model of HDV Infection;220 15;Subject Index;235
Casey, John
| ISBN | 9783540298021 |
|---|---|
| Artikelnummer | 9783540298021 |
| Medientyp | E-Book - PDF |
| Auflage | 2. Aufl. |
| Copyrightjahr | 2006 |
| Verlag | Springer-Verlag |
| Umfang | 228 Seiten |
| Sprache | Englisch |
| Kopierschutz | Digitales Wasserzeichen |
