The fourth edition of this leading book provides an authoritative, comprehensive and complete account of the neuronal disorders of the lower gastrointestinal tract in children. The book has been thoroughly revised and updated to reflect major advances that have occurred both in the understanding as well as the treatment of Hirschsprung's disease. 

Contents discuss the latest therapies such as stem cell therapies, the epidemiology and association with multiple endocrine neoplasia and approaches to diagnosis such as radiology and manometry as well as Hirschsprung's disease in adolescents and adults.

Surgical approaches are thoroughly covered and include a new chapter on intestinal transplantation options. The follow-up care and long-term outcomes of patients who have undergone therapy are also addressed in this edition.

With several new chapters added and the contents updated and re-worked, this edition is authored by the leading current experts in their respective fields. It is a must-have book for pediatric surgeons, pediatricians, gastroenterologists, and colorectal surgeons.

Hirschsprung's Disease: A Historical Perspective

Development of the Enteric Nervous system
Functional Anatomy of the Enteric System
Normal Colonic Morphology and Motor Function
Animal Models of Hirschsprung's Disease
Familial Hirschsprung's Disease
Genetics of Hirschsprung's Disease
Stem cell Therapy for Enteric neuropathies
Pathophysiology of Hirschsprung's Disease
Epidemiology and Clinical Characteristics of Hirschsprung's Disease
Associated Anomalies and Syndromes in Hirschsprung's Disease
Association between Hirschsprung's Disease and Multiple Endocrine Neoplasia Type 2a
Hirschsprung's Associated Enterocolitis
Radiological Diagnosis of Hirschsprung's Disease
Manometeric Diagnosis of Hirschsprung's Disease
Rectal Biopsy for the diagnosis of Hirschsprung's Disease
Histopathological Diagnosis of Hirschsprung's Disease
Total Colonic Aganglionosis
Hirschsprung's Disease in adolescents and adults
Variants of Hirschsprung's Disease
Megacystis-Microcolon-Intestinal Hypoperistalsis syndrome
Degenerative Hollow Visceral Myopathy Mimicking Hirschsprung's Disease
Transanal Pull-Through operation for rectosigmoid Hirschsprung's Disease
Laparoscopically Assisted Pull-Through operation for Hirschsprung's Disease
Redo Surgery for Hirschsprung's Disease
Early and late Complications following Pull-Through operation for Hirschsprung's Disease.-Morphological Basis of Persistent bowel problems following a properly performed pull-through operation for Hirschsprung's Disease
Bowel Management for the treatment of Chronic constipation and soiling in patients operated for Hirschsprung's Disease
Inflammatory Bowel Disease in patients with Hirschsprung's Disease
Intestinal Transplantation for Total Intestinal Aganglionosis
Urological and Sexual outcome in patients with Hirschsprung's Disease
Longterm Outcome and Quality of life after treatment of Hirschsprung's Disease.