Provides a unique summary of homologation strategies in organic synthesis

Homologation Reactions presents different concepts underpinning the use of homologating reagents as well as their applications in organic synthesis. It covers in-depth discussions on the rationales governing this kind of transformations with a strong emphasis on mechanistic elements modulating critical aspects (e.g. selectivity) of the processes. In addition, this two-volume work features:

• Metal carbenoids, ylides, and diazo reagents
• Homologating agents working under nucleophilic, electrophilic, and radical regime
• Homologations realized on boron-containing or carbon-centered linchpins
• Use of highly sensitive fluorinated homologating agents
• Progressive homologations and the concept of assembly line synthesis
• Homologation processes followed by rearrangement cascades
• Construction of cyclic motifs and ring-expansion
• Homologation reactions with carbon monoxide and carbon dioxide
• New and/or challenging directions to expect in the future

Written by an international team of leaders in the field, the book is a useful guide for designing effective transformations by using homologation reactions. It is a must-read for every synthetic chemist in academia and industry!

Vittorio Pace is Full Professor of Organic Chemistry at the University of Torino, Italy, since 2020. Before, he held a tenure-track professorship in Drug Synthesis at the University of Vienna, Austria. He received his habilitation (venia docendi) in Pharmaceutical Chemistry from the University of Vienna in 2016. He has been the recipient of different awards including the Ciamician Medal of the Italian Chemical Society, La Roche-Hoffmann Prize of the European Society of Medicinal Chemistry, the Thieme Award, and the Habilitation Award of the Austrian Chemical Society. Prof. Pace is an elected member of the Royal Spanish Academy of Pharmacy. His research is focused on the design and development of new synthetic concepts with functionalized organometallic reagents with a strong focus on homologation sequences.