An intimate relation between hormones and lipoprotein metabolism has been known for a long time especially from hormone-deficiency or -overproduction syndromes. The mechanisms through which hormones influence lipid metabolism have become a field of major interest in sci ence. The more we learn about cellular hormonal actions the better we understand regulatory processes and phenomena occuring in patients. The present book summarizes data discussed at an International Meet ing at Marburg, Germany, on "Hormones in Lipoprotein Metabolism". It was an attempt to pull together knowledge in basic science from the mode of action of hormones all the way to clinical appearance of hor monal disorders involving lipoprotein metabolism. Thus data on molec ular biology, on hormonal regulation of apolipoprotein synthesis, on lipoprotein receptors and enzyme induction are discussed together with the large field of oral contraceptive use, postmenopausal estrogen sub stitution, lipid disorders in diabetes mellitus, in thyroid dysfunction, in adrenal insufficiency and in glucocorticoid application. We are aware of the fact that such an overview cannot be complete but should serve as a collection of data and ideas for those interested in hormonal regulation of lipid metabolism. We thank all authors for taking an extra effort in writing up their presentations and thus making this edition possible. We also thank Bristol-Myers-Squibb for generous support of the meeting and of the final publication. Marburg, Germany ARMIN STEINMETZ JURGEN SCHNEIDER HANS KAFFARNIK Contents Molecular Biology Chairmen: D. J. Rader, A.

Molecular Biology

Interaction of Steroid Hormone Receptors with DNA
Hormonal Control of Genes Involved in Lipoprotein Metabolism in the Rat
Apolipoprotein B mRNA Editing: Modulation and Clinical Implications
Insulin, Diabetes mellitus, Obesity
Hormonal Regulation of Lipoprotein Metabolism in Obesity
Lipoproteins in Patients with NIDDM: Effects of Different Therapeutic Approaches
Postprandial Course of Triglycerides and the Atherogenic Lipoprotein Particle "IDL" in Type 2 Diabetics with Normal Fasting Values
Differences Between Basal and Postprandial Circadian Variation of Insulin Sensitivity in Healthy Subjects and Type 1 Diabetics
Effect of Fish Oil Concentrate on the Lipoprotein Profile in Patients Suffering from Diabetes mellitus Type II
Sex-Hormones - Mechanism of Action, Epidemiology
Pharmacology of Female Sex Hormones with Respect to Lipid and Lipoprotein Metabolism
Why Women Live Longer Than Men (or Why Can't a Man be More Like a Woman?)
Induction of the Hepatic Uptake of Lipoproteins by Estrogen
Changes in Serum Lipoprotein Profiles During Puberty - A Longitudinal Study of Dresden Schoolchildren
Coronary Risk in Women: Potential Role of Age, Lipoproteins, Haemostasis, and Hormones
Different Lipoprotein Patterns in Men and Women Examined by Coronary Angiography
Sex-Hormones - Action on Plasma Lipoproteins
Influence of Oral and Percutaneous Estrogen Therapy on the Lipoprotein Particle Profile of Postmenopausal Women
Effects of Different Oral Contraceptives on Apolipoprotein E
Effects of a New Oral Contraceptive Containing Ethinyl Estradiol Desogestrel on Plasma Lipoproteins and Apolipoproteins
Anabolic Steroids do not Change mRNA Levels and Protein Secretion of Apolipoprotein A-I and B-100 in HepG2 Cells
VLDLApoB-100 and ApoE Metabolism in Male Female Subjects Utilizing the Stable Isotope Technique
Testosterone Lowers Serum Concentrations of Lipoprotein Lp(a)
Hormones other than Sex Steroids
The Role and Mechanism of Glucocorticoids on the Modulation of Lipid and Lipoprotein Metabolism
Lipids and Lipoproteins in Thyroid Dysfunction
Incidence and Treatment of Hyperlipidemia in Primary and Secondary Adrenal Insufficiency
Cholesterol Lowering Effect of Simvastatin in Patients with Normal and Impaired Renal Function
Determinants for Coronary Atherosclerosis Regression. The Marburg Lipid Intervention Trial
Medical Imaging System and Their Use in the Diagnosis of Cerebral Attacks Caused by Metabolic Disorders.