This book summarizes the results of two symposia held on hydroxy-pyridones as antifungal agents organized on the occasion of the International Summit on Cutaneous Antifungal Therapy 1996 in Vancouver and the 19th World Congress of Dermatology 1997 in Sydney. Some of the papers deal with the basic mechanisms of action and how these translate into product features, e.g. activity spectrum. Other papers describe the unique properties of hydroxy-pyridones, such as high penetration into and through keratinic tissues or their activity as dual inhibitor on 5-lipoxygenase and cyclooxygenase which leads to a remarkable antiinflammatory effect. Last but not least various accounts are given which show how this unique product profile aids the treatment of various fungal diseases, especially onychomycosis.

1 Hydroxy-Pyridones Outstanding Biological Properties

2 Enzyme Histochemical Investigations of Candida albicans After Treatment with Rilopirox, a Novel Fungicidal Hydroxy-Pyridone
3 Can Ciclopirox Be Used as a Broad-Spectrum Anti-Infective Agent?
4 Studies of the Anti-Inflammatory Properties of Ciclopirox
5 Measurement of Ciclopirox Permeation Through Fingernail Models by Novel Spectroscopic Techniques
6 Dermatomycosis: A Multifactorial Disease
7 Efficacy of Topical Batrafen
8 Ciclopirox Gel Treatment of Scalp Seborrhoeic Dermatitis
9 Seborrhoeic Dermatitis and Dandruff, and Its Treatment With Ciclopirox Shampoo
10 Epidemiology of Mycological Infections in Children - in South America
11 Clinical Efficacy of Topical Ciclopirox Nail Lacquer: Double-Blind United States Studies on Onychomycosis
12 Dose Regimen Studies with Ciclopirox Nail Lacquer
13 Open Studies of Ciclopirox Nail Lacquer in Onychomycosis - A Review
14 Influence of Onychomycosis on the Quality of Life
15 Treatment of Onychomycosis: Pharmacoeconomic Aspects
16 The Safety Aspects of Systemic and Topical Antifungal Agents Used in the Management of Onychomycosis
17 Differential Diagnosis of Onychomycosis and Rationale for a Step-Therapy in Treating Nail Fungal Infection.