The rapidity of scientific progress over the last few years guarantees the utility of this new collection of state-of-the-art reviews on the immunology of aging, which is the result of extensive collaboration of more than sixty of the greatest thinkers and scholars in the field, in cooperation with a number of junior colleagues. The book summarizes current knowledge on the cellular and molecular aspects of the aging immune system and their clinical relevance, providing insights into the effects of the aging process on susceptibilities to those diseases most common among elders. The retrieval strategies used to slow down the decline in the immune system in the elderly are another subject detailed extensively. By providing a broad overview of immunosenescence and its consequences, as well as their potential modulation, this book will fill a gap in a timely manner. It will be of value to all immunologists, whether novice or experienced, as well as geriatricians and epidemiologists.

An Introduction on the old age and aging of the immune system

The immune system, a marker and modulator of the rate of aging
Age-associated alterations of pleiotropic stem cell and the therapeutic implication of stem cell therapy in aging
A role for epigenetic modulation of the innate immune response during aging
Basophil, eosinophil and neutrophil functions in the elderly
Dendritic cells and dysregulated immunity in the elderly
Natural killer cell immunosenescence and cancer in the elderly
Pattern recognition receptors and aging
Impact of ageing on T cell repertoire and immunity
T cell mediated immunity in the immunosenescence process
Biological and phenotypic alterations of T cells in aging
T cells seen from the metabolic and aging perspective
Age-related alterations in regulatory T cells
Effects of aging on B cells
The role of MicroRNAs in immunosenescence process
Immunogenetics of Aging
Aging immunity and infection
Influenza infection in the elderly
Optimising response to vaccination in the elderly
Nutrition, immunity and aging
Diet and immunosenescence
Dietary Intake and impact of zinc supplementation on the immune functions in elderly: nutrigenomic approach
Physiological and pathological role of reactive oxygen species in the immune cells
Oxidative stress in aging
Skin aging and the immune system
Aging immunity and the impact of physical exercise.