During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies.

Contens

Introduction: Recent advances in the pathogenesis of human immunodeficiency virus infection
Virologic and immunologic events in primary HIV infection
The role of viral dynamics in the pathogenesis of HIV disease and implications for antiviral therapy
Immune dysregulation and CD4+ T cell loss in HIV-1 infection
Studies on lymphoid tissue from HIV-infected individuals: implications for the design of therapeutic strategies
Mechanisms of resistance to HIV infection
HIV-1-specific cytotoxic T lymphocytes and the control of HIV-1 replication
Noncytolytic CD8 T cell-mediated suppression of HIV replication
Role of complement and Fc receptors in the pathogenesis of HIV-1 infection
Simian immunodeficiency virus as a model of HIV pathogenesis.