This volume is a product of a collaborative effort and attempts to provide a wide and up-to-date coverage of information regarding the biology and on the potential application of immunostimulatory DNA. ISS hold great promise for influencing the immune response and the authors anticipate that the high efficacy and low toxicity observed in animal models will translate into success in a variety of human clinical applications.

to immunostimulatory DNA sequences

The discovery of immunostimulatory DNA sequence
Mechanisms of immune stimulation by bacterial DNA
Activation of NK cell (human and mouse) by immunostimulatory DNA sequence
Activation of skin dendritic cells by immunostimulatory DNA
Rescue of B cells from apoptosis by immune stimulatory CpG DNA
The response of human B lymphocytes to oligodeoxynucleotides
Multiple effects of immunostimulatory DNA on T cells and the role of type I interferons
Pre-priming: a novel approach to DNA-based vaccination and immunomodulation
Signal transduction induced by immunostimulatory CpG DNA
Immunostimulatory DNA sequences and cancer therapy
Modulation of asthmatic response by immunostimulatory DNA sequences
The role of CpG in DNA vaccines
Mucosal adjuvanticity of immunostimulatory DNA sequences
Immunostimulatory DNA sequences help to eradicate intracellular pathogens
The antigenic properties of bacterial DNA in normal and aberrant immunity
The role of immunostimulatory CpG-DNA in septic shock
Activation of the innate immune system by CpG oligodeoxynucleotides: immunoprotective activity and safety.