1;Preface;52;Table of Contents;63;Corresponding Authors;104;The Socio- economic Burden of Musculoskeletal Infections;145;Orthopaedic Device- related Infections;245.1;Epidemiology and Classification of Septic Total Hip Replacement;255.2;Early Radiological Diagnosis and Differential Diagnosis of Infection in Orthopaedic Surgery;335.3;Bacterial Strategies of Implant Colonization and Resistance;455.4;Pathological Findings of Septic Loosening ;515.5;Antimicrobial Prophylaxis in Orthopaedic Surgery;615.6;The Limits of Systemic Antibiotics in Device- related Infections;705.7;Antibiotic Bone Cement as a Prophylactic Means in Joint Replacement Surgery;745.8;The Limits of the Local Antibiotic Therapy ;795.9;The Role of Suppressive Surgery;856;Basic Research and Local Antibiotic Therapy;896.1;PMMA as Drug Delivery System and in vivo Release from Spacers;906.2;Antibiotic Cement Spacers in Total Hip and Total Knee Arthroplasty: Problems, Pitfalls, and Avoiding Complications;1036.3;The Preformed Spacers: From the Idea to the Realization of an Industrial Device;1236.4;Fatigue and Wear Characterization of the Preformed Hip Spacer;1326.5;Fatigue Characterisation of the Preformed Knee Spacer;1396.6;Surface Analysis of the Spacer Before and After the Clinical Use;1476.7;Bone Loss: Does Use of the Spacer Affects it?;1596.8;Antibiotic Impregnated Bone Grafts - What Do We Know?;1656.9;Antibiotic- loaded Bone Allograft: Personal Experience;1716.10;Antibiotic Loaded Cement: From Research to Clinical Evidence;1817;Clinical Applications: Hip;1877.1;The Management of Infection in THA: A Historical Perspective;1887.2;Girdlestone Arthroplasty after Hip Prosthesis Infection - A Two- stage Revision;1987.3;One- stage Non- cemented Revision of Septic Hip Prosthesis Using Antibiotic- loaded Bone Graft;2037.4;Two- stage Revision of Infected Total Hip Arthroplasty. Comparison Between a Custom-made and a Preformed Spacer;2107.5;Two- stage Revision of Infected Total Hip Replacement Using a Preformed, Antibiotic- loaded Acrylic Cement Spacer;2147.6;Two- stage Revision of Septic Hip Prosthesis with Uncemented Implants;2237.7;Long- stem Preformed Spacers Followed by Uncemented Implants: A Solution for Wide Femoral Opening or Bone Loss in Two- stage Revision;2407.8;Two- stage Revision Surgery in Septic Total Hip Arthroplasty;2527.9;One- stage, Two- stage or Multi- stage Revision: the Reason of a Choice;2577.10;Analysis of the Gait in Patients with Hip Spacers;2678;Clinical Applications: Knee;2738.1;Septic Knee Prosthesis Revision: A Challenging Surgery;2748.2;Management of TKA Infection - One- stage Exchange;2798.3;Antibiotic- loaded Bone Cement Spacers for the Two- stage Revision in Total Knee Replacement;2938.4;Key Points in Two- stage Revision for Infected Knee Arthroplasty: Bone Loss, Quality of Life Between Stages and Surgical Approach at Second Stage;3018.5;Two- stage Revision with Preformed Knee Spacers and Modular Knee Prosthesis;3098.6;Arthrodesis for the Treatment of Severe Knee Disease;3168.7;Arthrodesis and Amputation in Knee Joint Infections;3278.8;Salvage Procedures in Exposed Septic Knee Prothesis;3359;Novel Applications and Perspectives;3439.1;The Management of the Shoulder Prosthesis Infection;3449.2;Shoulder Spacer as a Definitive Solution?;3499.3;The Gentamicin- Vancomycin Spacer: A Pharmacological Study;3579.4;Rationale of Nail Antibiotic Clothing and "in vivo" Animal Study;3649.5;The Use of Antibiotic- loaded Spacers in Post- traumatic Bone Infection;3729.6;The Use of Antibiotic- impregnated Cement in Infected Reconstructions after Resection for Bone Tumors;3829.7;Local Antibiotic Therapy: Present and Future ;390