This book provides an in-depth overview of the aetiology, treatment and prevention of infections following knee arthroplasty. It presents up-to-date information on available techniques and salvage procedures for complex patients with infected, total knee arthroplasty.

Divided into 5 sections, this book explores biomaterials, clinical manifestations, diagnosis, treatment and prevention, including preoperative optimisation, in order to reduce knee infections.

This book is a valuable reference resource for practicing orthopaedic surgeons, residents, and medical students wishing to understand the fundamental concepts in infectious disease medicine needed in current orthopaedic practice.

Epidemiology and socioeconomic impact of infections in knee replacement

Aetiology and pathogenesis of knee replacement infections.Biomaterials in artificial joint replacement. The role of the surface on bacteria-implant interactions
In-vitro and in-vivo models for the study of prosthetic joint infections. Clinical manifestation. General and local symptoms. Diagnosis. Laboratory diagnosis
Microbiological diagnosis
Molecular analysis and histological evaluation
Imaging
Definitional criteria and algorithms of diagnosis. Treatment of knee replacement infections. Systemic antibiotic therapy
Innovative pharmacological strategies
Surgical approaches
DAIR 
One stage
Two stage
Static spacers
Dynamic spacers
Arthrodesis
Outcomes
Complications
Resistant germs. Current evidence on prevention of knee replacement infections. Medical optimization of patient prior to surgery
Antibiotic prophylaxis during primary and revision joint replacement
Preoperative management
Intraoperative management
Dental Procedures after joint replacement
Thromboprophylaxis and haematomas
Antibiotic impregnated cement
Arthroplasty following Prior septic arthritis
Antibiotic-loaded cement in primary and revision joint replacement
Operative Room
Tourniquet
Intraarticular injection prior Joint replacement.