The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmon ize toxicologic testing, to advance a more uniform inter pretation of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scien tists. The Monographs on the Pathology of Laboratory Ani mals are designed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others concerned with evaluating toxicity and carcinogen icity studies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors - strengthens our ex pectations that understanding and cooperation will be im proved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on the integumentary system, is the seventh volume of a set prepared under the sponsorship of the International Life Sciences Institute (ILSI).

The Integument

General
New Approaches and Diagnostic Techniques in Dermatopathology
Neoplasms
Squamous Cell Papilloma, Skin, Rat
Squamous Cell Papilloma, Skin, Mouse
Squamous Cell Carcinoma, Skin, Rat
Squamous Cell Carcinoma, Skin, Mouse
Squamous Cell Carcinoma Arising in Induced Papilloma, Skin, Mouse
Basal Cell Carcinoma, Skin, Rat
Basal Cell Tumor, Skin, Mouse
Trichoepithelioma, Skin, Rat
Melanocytic Tumors, Skin, Mouse
Melanocytic Tumors, Skin, Hamster
Melanocytic Tumors, Rat
Fibroma, Dermis and Subcutis, Rat
Fibrosarcoma, Dermis and Subcutis, Rat
Fibroma, Dermis and Subcutis, Mouse (Especially B6C3F1 Mouse)
Fibrosarcoma, Dermis and Subcutis, Mouse
Lipoma, Subcutis, Rat
Liposarcoma, Subcutis, Rat
Fibrous Histiocytoma, Malignant, Subcutis, Rat
Mast Cell Tumor, Skin, Mouse
Clitoral Gland Tumors, Mouse
Hibernoma, Rat
Nonneoplastic Lesions
Epidermal Inclusion Cyst, Skin, Rat
Alopecia, Rat and Mouse
Cutaneous Sensitization, Experimental, Mouse, Hamster, Rat
Steatitis, Subcutaneous and Generalized, Rat
Follicular Hyperkeratosis, Induced, Rabbit Ear
Viral Infections
Mousepox, Skin, Mouse
Papillomavirus Infection, Skin, Mouse
Inherited Conditions
Obese Mutant Mice: Obese (ob) and Diabetes (db)
The Skin of the Rhino Mouse
Hairless Mouse, HRS/J hr/hr
Skin of the Pupoid Fetus (pf/pf) Mutant Mouse
Skin of the Repeated Epilation (Er/Er) Mutant Mouse
The Tight Skin (TSK) Mouse
Asebia, a Mutation Affecting Sebaceous Glands, Mouse
Ichthyosis, Inherited, Skin, Mouse (ic/ic)
The Mammary Gland
Structure and Function
Morphology and Development of the Rat Mammary Gland
Endocrine Influences on the Mammary Gland
Histologic/Immunocytochemical Markers, Mammary Gland, Rat
Neoplasms
Classification of Neoplastic and Nonneoplastic Lesions of the Rat Mammary Gland
Factors That Modulate Chemical Carcinogenesis in the Mammary Gland of the Female Rat
Markers in Chemically Induced Tumors, Mammary Gland, Rat
Adenoacanthoma, Mammary Gland, Mouse
Mixed Adenocarcinoma, Mammary Gland, Mouse.