The presented information reflects a state-of-the-art summary of the pleiotropic effects of IL-10 in vitro and in vivo and will contribute to our understanding of the role of ILj-10 in the immune system and its potential clinicial utility in the near future. The book contains chapters in which the in vitro biological effects of IL-10 on both mouse and human lymphoid and myeloid cells are reviewed. In addition, the role of IL-10 in transplantation, parasite infections, inflammation, infectious diseases and bone formation is described. The effects of IL-10 in vivo are presented, describing an IL-10 transgenic mouse model, the IL-10 "knock-out" mouse, and the capacity of IL-10 to prevent lethal toxic shock in mice.

1. Molecular Biology of Interleukin-10 and its Receptor

2. Physicochemical and Structural Properties of Interleukin-10
3. IL-10 and Human T Cells
4. Interleukin-10 and B Lymphocytes
5. Regulation of Human Monocyte Functions by Interleukin-10
6. Interleukin-10: An Inhibitor of Macrophage-Dependent Stimulation of Th1 Cells
7. IL-10 and Bone Formation/Hematopoiesis
8. Regulatory Function of IL-10 in Experimental Parasitic Infections
9. IL-10 in Mycobacterial Infection
10. IL-10 In Human Leishmaniasis
11. IL-10 and HIV-1 Replication
12. Interleukin-10 and Transplantation Tolerance
13. Effects Of IL-10 in Lipopolysaccharide- and Superantigen-Induced Lethal Shock In Vivo
14. Inhibition of Cell-Mediated Immune Responses In Vivo by Recombinant IL-10
15. IL-10 Transgenic Mice
16. Interleukin-10 Deficient Mice
17. A Phase I Study of Interleukin-10 in Healthy Humans: Safety and Effects on Cytokine Production.