Cancer is a very aggressive disease and currently it has been considered a challenge to oncologists and cancer patients worldwide. Nowadays, several therapeutic strategies had improved toward last decades. Surgery is many times still the best curative treatment, mainly in early stage disease. However, Radiotherapy and chemotherapy acquired a main role in this scenario. Target therapies were introduced for medical oncology practice and are demonstrating a hallmark of a new era in cancer treatment. More recently, immunotherapy has been considered the novel cornerstone in cancer treatment. The 2 nd edition of the International Manual of Oncology Practice (iMOP) emerged after the great success of the iMOP 1 st edition as a reference for medical oncologists and medical residents in the field. In this edition, several chapters were revised and its addresses from the molecular issues of cancer sciences to the clinical practice in medical oncology. In addition, multiple choice questions and clinical cases were included in the main chapters in order to improve the reader learning. The book focuses systemic treatments in many areas of medical oncology, such as breast cancer, gastrointestinal, thoracic, urological oncology, head and neck tumors, bone tumors, sarcomas and palliative care. The topics herein discussed will provide the readers a step forward in the medical oncology practice understanding and give facilities for help in cancer patient treatments.

Ramon Andrade de Mello, MD, PhD

University of Algarve, Portugal

Ramon Andrade Bezerra de Mello received the MD degree at the Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil, with MD recognition from University of Lisbon, Portugal, and holds the Certificate in Medical Oncology by passing the European examination of ESMO (European Society for Medical Oncology), Lugano, Switzerland. He completed specialization in medicine and molecular oncology and his PhD in Oncology (lung cancer) at the Faculty of Medicine, University of Porto, Portugal. He also completed a post-doctoral clinical research fellowship in lung cancer clinical trials at the Lung Unit, Royal Marsden NHS Foundation Trust, Chelsea, London, United Kingdom, supported by the ESMO. Currently, he works in the Department of Medical Oncology at the Portuguese Oncology Institute, Porto, Portugal, and he teaches at the Department of Medicine of the University of Porto and School of Medicine, University of Algarve, Faro, Portugal. He is medical director of Oncoclínica/Euroclinics, Porto, Portugal. Prof. de Mello performs both basic and clinical research on angiogenesis, palliative medicine, internal medicine, colorectal cancer and lung cancer; further, he has an active office working. He is editor of 2 books (Tamoxifen Concepts and Cancer: New Paradigms and Vimentin Concepts and Molecular Mechanisms, Nova Science, NY, USA, 2013), author of several scientific articles, chapters and comments on basic and clinical research. He presented more than 50 papers in congresses and conferences in several countries, such as United States, Sweden, Brazil, Portugal and Spain. Furthermore, he serves as editorial board of several reputed scientific journals, such as PLoS ONE, Rare tumors, Oncology Reviews and scientific reviewer of the British Journal of Cancer, Journal of Thoracic Oncology, Annals of Internal Medicine and The Lancet. He participates as expert reviewer of grant applications at the University of Coimbra, Portugal, National Science Centre, Kraków, Poland, and the British Lung Foundation, London, UK. Prof. de Mello is an active member of the ESMO Young Oncologist Committee and consultant at Pfizer gastric cancer advisory board.

SHORT CV GIANNIS MOUNTZIOS MD, MSc, PhD

Dr Giannis Mountzios was born in Larissa, Greece, in 1974. He obtained his medical degree (MD) from the Aristotle University of Thessaloniki in 1998 with a scholarship from the Greek Ministry of Education and graduated from the