Cancer is a very aggressive disease and currently it has been considered a challenge to oncologists and cancer patients worldwide. Nowadays, several therapeutic strategies had improved toward last decades. Surgery is many times still the best curative treatment, mainly in early stage disease. However, Radiotherapy and chemotherapy acquired a main role in this scenario. Target therapies were introduced for medical oncology practice and are demonstrating a hallmark of a new era in cancer treatment. More recently, immunotherapy has been considered the novel cornerstone in cancer treatment. The 2^nd edition of the International Manual of Oncology Practice (iMOP) emerged after the great success of the iMOP 1^st edition as a reference for medical oncologists and medical residents in the field. In this edition, several chapters were revised and its addresses from the molecular issues of cancer sciences to the clinical practice in medical oncology. In addition, multiplechoice questions and clinical cases were included in the main chapters in order to improve the reader learning. The book focuses systemic treatments in many areas of medical oncology, such as breast cancer, gastrointestinal, thoracic, urological oncology, head and neck tumors, bone tumors, sarcomas and palliative care. The topics herein discussed will provide the readers a step forward in the medical oncology practice understanding and give facilities for help in cancer patient treatments.   

Preface

Cancer screening and epidemiology
Cancer stem cells
Apoptosis
Angiogenesis
Genetic basis of metastasis
Anti-cancer Drugs
Immuno-oncology
Health Econimics
Small cell lung cancer
Mesothelioma
Thymus
Breast
Oesophageal
Gastric
Colon
Rectal
Anal Canal Cancer
Small intestine
Liver Cancer
Pancreatic Cancer.- Ovarian
Cervical
Vagina
Gestacional trophoblastic disease
Prostate Cancer
Renal Cell Carcinoma
Urothelial Cancer
Germ-Cell Tumors
Penile Cancer
Squamous Head and neck
Thyroid cancer
Parotid Gland Tumors
Melanoma
Soft Tissue Sarcomas
Bone Sarcomas
GIST
NET
Primary brain tumor
Acute Lymphoblastic Leukemia
Myelodisplastic Syndrome
Metabolic disturbance/paraneoplasic syndromes
Spinal medular compression
Superior vena cava syndrome
Febrile neutropenia
Chemotherapy-Induced Nausea and Vomiting
Asthenia
Oncological pain
Bone Metastases
Brain metastasis
Palliative care
Index.