Current problems in research and treatment of leukemias as discussed at the symposium of the International Society of Haematology on leukemias in Dresden (Germany) are dealt with in detail in this volume. The characterization of leukemic cells and the evaluation of their function are themes, with the first hints emerging of the possibility of relating them to the intensity of treatment required. The cytokines, responsible for cooperation between cells, are also of great importance, and the beginnings of therapeutic applications can be discerned here. Not only are the cytokines themselves very interesting, but also the application of cells producing cytokines according to the range of macrophages found. The emphasis on cell-to-cell relationship is thus a main topic of the book. Of course, other treatment such as bone marrow transplantation and interferon therapy play an important part, too, and the latest results of chemotherapy are reported. A further essential area covered is the diagnosis and therapy of chronic leukemic diseases, the inclusion of which suitably rounds off the book. I am very grateful to the out standing specialists from both the West and the East who contributed to the symposium and this book: an important sign of collaboration and integration for the future.

The Blast Cell of Acute Leukemias

Prognosis of Myelodysplasic Syndromes
Megakaryocytopoiesis in Patients with Myelodysplastic Syndromes
Diversity of Bone Marrow Findings in Chronic Myelomonocytic Leukemia
Nucleolar Organizer Regions in Acute Leukemia
A Further Note on the Ultrastructure of Human Leukemic Cells
Cell Kinetics of Human Acute Leukemia: In Vivo Study with Bromodeoxyuridine and Flow Cytometry
Clinical, Biochemical and Cytokinetic Parameters for Distinguishing Smouldering and Rapidly Proliferating Variants of Acute Leukemia
Dimethylsulfoxide and Retinoic Acid-Induced Differentiation and Commitment in HL-60 Cells
Immunophenotyping of Adult Acute Leukemia by Immuno-Alkaline Phosphatase Labeling
Diagnostic and Prognostic Value of Immunological Leukemia Phenotyping
Immunoelectron Microscopy of Megakaryoblasts in Megakaryoblastic Transformation of Chronic Granulocytic Leukemia
Thymidine Kinase in Leukemic Cells: Significance for Characterization and Follow-Up of Acute Leukemia
Bleeding Tendency in Acute Promyelocytic Leukemia: Reversal by Cell Differentiation?
Risk Prediction of Therapy-Induced Leukemia After Cytostatic Treatment
Cytokines and Macrophages
The Role of Cytokines in Experimental and Clinical Hematology
Hematopoietins: New Tools in the Treatment of Hematopoietic Insufficiency
Interleukin-1 and Tumor Necrosis Factor Production in Acute Nonlymphoid Leukemia
Interleukin-2: Biological Activities and Clinical Relevance in Advanced Stage Human Cancer
Interleukin-2 in the Treatment of Cancer Disease: Introduction of a Therapeutic Model and some Immunological Data
Enhancement of Growth of Murine Colony-Forming Units-Granulocyte-Macrophage at Suboptimal Colony-Stimulating Factor-Granulocyte-Macrophage Concentrations by Nucleosides, Nucleobases and Their Analogues, and the Dimer of the Hemoregulatory Pentapeptide
Induction of Lymphokine-Activated Killer Cells from Human Leukemic T Cells by Interleukin-2
The Influence of Recombinant Human Granulocyte-Monocyte-Colony-Stimulating Factor on Stroma Formation by Normal Human Bone Marrow Cells In Vitro
Adoptive Transfer of Autologous Cytotoxic Macrophages Grown from Blood Monocytes. A New Approach to Cancer Immunotherapy
Interferon Therapy
Strategies for Optimizing Cytokine Treatment of Malignancies: Determination of Interferon Sensitivity in Chronic Myelocytic Leukemia
Clinical Study with Human Recombinant Interferon-?2a in Chronic Myeloid Leukemia. Protocol of the Italian Cooperative Study Group on Chronic Myeloid Leukemia: Preliminary Analysis of Results
Alpha-Interferon in Hematological Disorders with Special Emphasis on Chronic Myeloid Leukemia
Long-Term Treatment with Alpha-Interferon of Excessive Thrombocytosis in Myeloproliferative Disorders
Sustained Remission After Interferon Treatment for Essential Thrombocythemia
Treatment of Chronic Myeloproliferative Disorders with Interferon-?
Interferon-? and Hairy Cell Leukemia
Bone Marrow Transplantation
Allogeneic Marrow Transplantation for Acute Leukemia
Allogeneic Bone Marrow Transplantation: State of the Art and Future Directions
Bone Marrow Transplantation for Leukemia in Europe
Bone Marrow Transplantation in Acute Leukemias and Chronic Myeloid Leukemia
Bone Marrow Transplantation for Chronic Myeloid Leukemia in France. Results of the French Cooperative Group
National and International Experiences with Autologous Bone Marrow Transplantation in Acute Leukemias
CD48 Monoclonal Antibody K31 for Bone Marrow Transplantation: Functional Characteristics
Comparison of the Growth of Xenografted Human Bone Marrow with the Growth of Xenografted Acute Myeloid Leukemia Cells and Marrow Repopulating Capacity Following Transplantation into Allogeneic Recipients
Chemotherapy of Acute Leukemias
Cellular Pharmacokinetics of Daunomycin in Human Leukemic Blasts In Vitro and In Vivo
Detection of the Multidrug Resistance Phenotype in Leukemic Cells with an In Vitro Chemosensitivity Assay
Chemotherapy for Adult Acute Myeloid Leukemia: Study Results from the Acute Myeloid Leukemia Cooperative Group and Overview
Mitoxantrone and Cytosine Arabinoside as First-Line Therapy in Elderly Patients with Acute Myeloid Leukemia
Intermediate-Dose Cytosine Arabinoside and Amsacrine for Remission Induction and High-Dose Cytosine Arabinoside and Amsacrine for Intensive Consolidation in Relapsed and Refractory Adult Acute Myelogenous Leukemia
Aclacinomycin A Therapy in Acute Nonlymphoblastic Leukemia
Therapy of Blastic Transformation of Chronic Myeloid Leukemia
Chronic Myeloproliferative Diseases and Chronic Lymphatic Leukemia
Hanover Classification of Chronic Myeloproliferative Diseases by Histopathology of the Bone Marrow
Chronic Myeloproliferative Syndromes: Initial Findings, Evolution, and Prognosis in 489 Patients
Histomorphological and Cytogenetic Investigations in Chronic Myeloproliferative Diseases
Chronic Megakaryocytic-Granulocytic Myelosis: Accuracy of Clinical Diagnosis of Chronic Myeloproliferative Disorders with Thrombocytosis
Morphology of Megakaryocytes in Chronic Myeloproliferative Diseases
The Megakaryocytic Myeloid Leukemia: Clinical, Morphological and Functional Aspects
Budd-Chiari Syndrome and Other Abdominal Thromboses in the Chronic Myeloproliferative Disorders
New Therapy of Myelofibrosis with an Antifibrotic Substance and a Macrophage Stimulant
Preliminary Results of a Multicenter Study of Chronic Myelogenous Leukemia Comparing Busulfan/6-Mercaptopurine with Dibromomannitol/6-Mercaptopurine
Ag-NOR in B-Cell Chronic Lymphocytic Leukemia: Pathomorphological Subtypes of the Disease
Flow Cytochemical Analysis of Lymphoid Cells in B-Chronic Lymphocytic Leukemia (B-CLL)
Immunodiagnosis of Leukemic Blood Cells of Patients with Chronic Lymphocytic Leukemia and Other Non-Hodgkin's Lymphomas by Monoclonal Antibodies of the Biowissenschaften Leipzig Series
Advanced and Terminal Phase of B-Cell Chronic Lymphocytic Leukemia.