Effective treatment of acute myocardial infarction remains one of the major issues in cardiology and internal medicine. The present monograph summarizes the relevant experimental data and the results of major clinical trials in the treatment of myocardial infarction. There are contributions of fundamental anatomical and physiological concepts of vascular occlusion and myocardial damage due to ischemia as well as discussions of therapeutic strategies involving thrombolytic agents, adjuvant drug therapy for limitation of myocardial damage, improvement in myocardial tolerance to ischemia and prevention of coronary reocclusion. In this regard, there is an extensive discussion of the role of coronary angioplasty and bypass surgery in the setting of acute myocardial infarction.

Pathogenesis and Pathophysiology of Coronary Occlusion

Can Infarct Size Be Limited? Prospects for "Injury-Delaying" Therapy
Pathophysiology of Evolving Myocardial Infarction
The Pathogenesis of Thrombosis in Human Atherosclerotic Coronary Arteries
Thrombogenesis and Vascular Occlusion
Evaluation of Myocardial Perfusion by Means of Contrast Echocardiography
Discussion (edited by R. Parratt)
Limitation of Infarct Size by Nonthrombolytic Drugs
Estimation of Acute Infarct Size In Vivo
Pharmacology of Cardioprotection
Calcium Antagonists and Ischaemia: A Critical Evaluation
Can Myocardial Infarction Be Prevented or Limited by Nonthrombolytic Drugs?
Newer Aspects of Drug Therapy: Free Radical Scavengers
Stimulation of Vascular Prostacyclin Formation by Defibrotide: A New Strategy for Treatment of Acute Myocardial Ischaemia
Discussion (edited by P. Lichtlen)
Limitation of Infarct Size by Thrombolytic Therapy
Thrombolytic Therapy: State of the Art
Early and Prehospital Thrombolytic Therapy in Acute Myocardial Infarction
Status of Thrombolytic Therapy in Acute Myocardial Infarction in France
Adjuvant Therapy for Coronary Reperfusion in Evolving Acute Myocardial Infarction
Perspectives on Newer Thrombolytic Agents
Discussion (edited by F. C. Dougherty)
Follow-up Therapy after Thrombolysis
Is Immediate Angioplasty Required to Restore Coronary Blood Flow at Rest After Recanalisation with Intravenous Recombinant Tissue-Type Plasminogen Activator in Patients with Acute Myocardial Infarction?
Angioplasty After Thrombolysis: Early and Late Angiographic Results
PTCA in Acute Myocardial Infarction
What is the Place of Surgery Soon After Thrombolysis?
The Use of Cardiovascular Drugs Following Thrombolysis in Humans
Discussion(edited by F. C. Dougherty)
Prevention of Occlusion or Reocclusion
Factors Influencing the Rate of Coronary Artery Occlusion and Reocclusion
Which Antithrombotic Therapy Has Proven Most Effective for the Treatment of Deep Arterial Injury, Ruptured Plaque, and Post-Thrombolysis?
Agents Effective in the Limitation of Myocardial Ischaemic Damage: Present Concepts and Future Possibilities
Discussion (edited by F. C. Dougherty)
Therapeutic Strategies for Limitation of Infarct Size
Panel members.