The meeting on "Molecular Mechanisms of Lipid and Protein Traffic", sponsored by NATO Scientific Affairs Division as an Advanced Study Institute and by the Federation of European Biochemical Societies as a Lecture Course was held in Cargese, France, in June 1997. The program included introductory lectures, specialized up-to-date contributions, poster sessions, tutorials and workshops. Emphasis was laid on the new developments in the field of membrane dynamics, in particular on the insertion and translocation of proteins; on intracellular protein, lipid and membrane traffic and sorting and on the mutual interactions between the various events occurring during membrane biogenesis. Mitochondrial biogenesis, chloroplast assembly and the insertion of proteins into peroxisomes were highlighted. Much progress in these research areas has been made in recent years and the ASI provided an excellent opportunity to illustrate this progress in comparison with previous meetings on a similar topic. Not only graduate students and postdocs took advantage from this program but also experienced scientists were given the opportunity to obtain a complete overview of recent progress and the remodeling of ideas and concepts.

Import, Folding and Degradation of Proteins by Mitochondria

Protein Complexes Involved in Import of Mitochondrial Preproteins
Protein Targeting into and within Chloroplasts
Chaperone Action in Folding Newly-Translated Cytosolic Proteins in Bacteria and Eukaryotes
Biogenesis of Peroxisomes
Molecular Dissection of Clathrin Coat Formation and Receptor Sorting
A Function for EGF-Induced Eps 15 Ubiquitination in Endocytosis
The Role of ?2Macroglobulin Receptor Associated Protein as a Chaperone for Multifunctional Receptors
Characterization of the Gene VII and Gene IX Minor Coat Proteins from Bacteriophage M13
Lipoprotein Sorting in Escherichia coli
In Vitro Studies of the Interactions between Signal Peptides and Signal Recognition Factors
A PreS1-Specific Sequence Determines the Dual Topology of the Hepatitis B Virus Large Envelope Protein and Binds the Heat Shock Protein Hsc70
Characterization of Components of the General Secretion Pathway of Aeromonas hydrophila
Do the Type I Signal Peptidases of Bacillus subtilis Compete for Binding and Cleavage of Secretory Precursor Proteins?
Studies on N-Glycosylation of Proteins in the Endoplasmic Reticulum
Role of COP Coats and GTPases in Transport of Cargo through the Early Secretory Pathway
Mapping the Golgi Retention Signal in the Cytoplasmic Tail of the Uukuniemi Virus G1 Glycoprotein
REP-Mediated Protein Prenylation
Development of a Positive Screen for the Identification of Suppressive Mutations in Secretion Defective Strains of Pseudomonas aeruginosa
Mitotic Division of the Golgi Apparatus
Vacuole Inheritance: A New Window on Interorganelle Traffic
Sea Urchin Nuclear Envelope Assembly in Vitro
Cell Vesicle Trafficking and Bacterial Protein Toxins
Pore-Forming Antimicrobial Peptidesand Polypeptides: Mechanisms of Insertion into Membranes and Mode of Action
Potassium Channels in Escherichia coli
A Link between Fatty Acid Synthesis and Organelle Structure in Yeast
Lipid Translocation from the Cytosolic Leaflet of the Plasma Membrane to the Cell Surface by Multidrug Transporters
Mycobacterial Glycopeptidolipid Interactions with Membranes: an Air-Water Monolayer Study by FTIR Spectroscopy
Consequences of Hydrophobic Matching on the Lateral Distribution of Lipids around Bacteriorhodopsin Reconstituted in DLPC/DSPC Mixtures
Translocation of Phospholipids between the Endoplasmic Reticulum and Mitochondria in Yeast
Lipid Peroxidation in Myocardial Cells under Ischemia and Oxidative Stress. The Effect of Allopurinol and Oxypurinol.