The third edition of this acclaimed work provides clinicians and investigators with a wealth of state-of-the-art information that will lead to fresh approaches in thinking about liver physiology and liver diseases.  Developed by a panel of renowned international authors, this edition outlines a range of important advances in our understanding of the liver's role as an immune organ and the functions of innate and adaptive immunity in the pathogenesis of all liver diseases.  Indeed, the liver is a vitally important immune organ producing liver-derived products that can trigger the innate and adaptive immune system to initiate, mediate, regulate, and resolve systemic inflammation.  

 

The book begins with an analysis of the core concepts of immunology, including the definition of autoimmunity and its unique application to the liver, a tolerogenic organ. Subsequent chapters then explore the biological elements of liver diseases caused by epigenetics, genetics, and innate and adaptive immunity. Specific clinical presentations and aspects of liver diseases are also examined, such as Hepatitis C, non-alcoholic fatty liver disease and parasitic infections.  Closing chapters then discuss liver diseases among specific populations, including pediatrics, those with comorbidities and preexisting conditions, pregnant women, and finally patients with transplanted organs.   

 

A timely and invaluable update to the clinical literature, Liver Immunology: Principles and Practice, Third Edition, is once again a comprehensive work that will not only enhance the understanding of liver diseases but also provide the kind of novel insights that greatly accelerates the evidence-based care of children and adults afflicted with these diseases. This volume is again a must-read for clinicians at all levels, for investigators and for students.

 

<p>1. Core Concepts in Immunology: The Definition of Autoimmunity and Its Unique Application to the Seat of Tolerance, the Liver

2. The Liver as a Lymphoid Organ
3. The Uniqueness of Innate Immunity
4. Adaptive Immunity and the Clinical Definition of Autoantibodies.-5. Genetics of Autoimmune Liver Diseases
6. The Epigenetic Basis of Loss of Tolerance
7. Bile Acids and Bilirubin in Liver Immunology
8. The Microbiota-Gut-Liver Axis - Implications for the Pathophysiology of Liver Disease
9. Diagnostic Liver Immunology
10. The Pathologist's Approach to Reviewing Liver Histology
11. Geoepidemiology of Autoimmune Liver Diseases
12. Immune Responses to Bacterial Infections
13. Immunity of Parasitic Infections of the Liver
14. The Treatment of Bacterial and Parasitic Diseases of the Liver
15. Hepatitis A and Other Viral Infections
16. Hepatitis B Virus
17. Hepatitis C
18. Hepatitis D
19. Hepatitis E
20. Alcohol-Associated Liver Disease
21. Non-alcoholic Fatty Liver Disease: A Chapter in Liver Immunology
22. Primary Biliary Cholangitis
23. PSC - AIH Overlap
24. Primary Biliary Cholangitis: Autoimmune Hepatitis Overlap Syndrome
25. Primary Sclerosing Cholangitis
26. Autoimmune Hepatitis
27. IgG4-related Disease: Current Concept, Diagnosis, and Pathogenesis
28. Pediatric Liver Disease
29. Mechanisms of Acute Liver Failure
30. Immune-Mediated Drug-Induced Liver Injury
31. Hepatobiliary Cancers and Immunology
32. Acute-on-Chronic Liver Failure
33. The Pathogenesis of Liver Diseases in Pregnancy
34. Graft-Versus-Host Disease
35. Immunopathogenesis of Liver Cirrhosis
36. Immune-Mediated Liver Disease in the Transplanted Liver.<br></p>