For the first time a complete review of the research work done over the past 30 years by leading investigators around the world in targeting immunosuppressants to both solid-organ and cellular transplants is available in a single volume. One section consists of studies conducted in rat allograft models using osmotic minipumps for delivery of a variety of immunosuppressants. The book will be of great benefit to researchers in the fields of transplant immunology, pharmacology and drug delivery and targeting, particularly those involved in drug development.

Section A: Background

1. Local Regulation of Allograft Rejection
2. Pharmacokinetic Advantage of Regional Drug Delivery
3. Early Studies of Local Immunosuppression (1964-1984)
Section B: Pump-Based Local Infusion in Rat Allograft Models
4. Selective Immunosuppression by Local Treatment of the Allograft: Studies on Intrarenal Prednisolone and Intracardiac Budesonide Delivery in the Rat
5. Local Immunosuppression of Rat Cardiac, Liver, and Small Bowel Allografts
6. Inhibition of Cardiac Allograft Rejection by Continuous Local Infusion of 16,16 Di-Methyl PGE2
7. Intrarenal Administration of Anti T Cell-Monoclonal Antibody
8. Intraportal Delivery of Immunosuppressants to Intrahepatic Islet Allografts
Section C: Pump-Based Local Infusion in Canine Allograft Models
9. Local Heparin, 6-Mercaptopurine, Prednisolone, and Mizoribine Delivery in a Canine Renal Allograft Model
10. Intraportal Cyclosporine A in Canine Liver Transplantation
Section D: Other Drug Targeting Systems for Achieving Local Immunosuppression
11. Liposomal Cyclosporine A
12. Liposomal FK506 in a Canine Hepatic Allograft Model
13. Cyclosporine Aerosol in Lung Transplantation
14. Site-Specific Immunosuppression with Topical Agents
15. Local Immunosuppression in Corneal Transplantation
16. Controlled-Release Drug Matrices for Local Immunosuppression of Organ Transplants
17. Gene Transfer to the Transplanted Organ
18. Immunomodulation of Islet Allografts with Genetically Modified Muscle Cells
19. Sertoli Cells in Islet Transplantation: Testicular Immune Privilege
Section E: Conclusion.