This volume brings some of the worlds best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two. The opening chapters discuss antimalarials and resistance to them in Africa and Asia. Then there are reviews of the different clinical manifestations of malaria, ranging from uncomplicated infections to severe disease and its complications. This section is followed by detailed reviews of what the new omics offer to investigators of Plasmodium biology and is completed by descriptions of advances in understanding the biology of Plasmodium in the mosquito. If this volume attracts new students and provokes existing investigators to explore new directions, then it will have achieved much of what it has set out to do.

Drugs and drug resistance

Quinolines and Artemisinins: Chemistry, Biology and History
Antimalarial multidrug resistance in Asia: mechanisms and assessment
Antimalarial drug resistance in Africa: strategies for monitoring and deterrence
Malaria the disease
Uncomplicated malaria
Metabolic complications of severe malaria
The clinical and pathophysiological features of malarial anaemia
Malaria in the pregnant woman
Biology
Host receptors in malaria merozoite invasion
A post-genomic view of the mitochondrion in malarial parasites
The plastid of Plasmodium spp. a target for inhibitors
Hemoglobin degredation
Bioavailable iron and heme metabolism in Plasmodium falciparum
Plasmodium permiomics: membrane transport proteins in the malaria parasite
Plasmodium ookinete invasion of the mosquito midgut
Molecular genetics of the mosquito resistance to malaria parasites
Functional proteome and expression analysis of sporozoites and hepatic stages of malaria development
Subject index