More than 150 years have passed since involvement of the nervous system in leukemia was first reported by BURNS, while the possibility of the primary brain tumor derived from the lymphoreticular tissue was recognized much later. BAILEY in 1929 described such neoplasms under the term perithelial sarcoma. Later these tumors of the nervous system have been variously designated as "Perivascular of perithelial sarcomas, reticulum cell sarcomas or microgliomas", as controversy has evolved and still exists on the definition of this group of neoplasms and on the nature of their cells of origin. Much of the unfortunate confusion concerning the neoplastic lesions attributed to "microglia" and other derivations of the RE system arose because their close relationship to extra neural cells has been ignored. On the other hand, communication in the field of malignant lymphomas has become increasingly difficult because of the termino logic maze and conceptual diversities of traditional morphological classifica tions that have limited valid comparisons. Although at present we are still far from a precise recognition of the basic features of lymphoproliferative processes and from a fairly general agreement on the terminology of non-Hodgkin lymphomas, there is encouraging evidence recently of some enlightment on the nature of tumor cells that provides the basis for a reasonable and generally acceptable lymphoma classification.

Morphology and Classification of Malignant Lymphomas and So-called Reticulosis

Ultrastructural Features of Human Lymphomas
Morphological Classification of Malignant Lymphomas: Ultrastructural, Cytochemical and Immunological Results
Classification of Malignant Lymphomas by Means of Membrane Markers
Differentiation of Lymphoid Cells of the Cell Series According to Membrane and Cytoplasmic Determinants
Studies of the Mechanism of Growth Promotion of Lymphoma Cells by 2-Mercaptoethanol in vitro
Myxovirus-Like Particles in Cells of American Burkitt's-Type Lymphoma
Acid Phosphatase of Azurophilic Granules of C3HST4 Lymphoma
The Fine Structure of the Lymphocyte Nucleus Under Conditions of Phytohaemagglutinin Stimulation
Studies on Lymphocyte Sensitization to Encephalitogenic Protein in Tumor Patients
Malignant Lymphomas of the Nervous System
Lymphoreticular Proliferative Disorders of the CNS and Other Organs: Analogies and Differences
Neoplastic Involvement of the CNS in Generalized Lymphomas
Primary Lymphoreticuloses of the Nervous System in Animals
Pathology of Primary Reticulum Cell Sarcoma of the Human Central Nervous System
Primary Malignant Lymphomas of the Central Nervous System in Man
Primary Lymphomas of the Central Nervous System; in vitro Culture Observations
Primary and Borderline Brain Lymphosarcoma: A Neuropathological Review of Nine Cases
Microglioma and/or Reticulosarcoma of the Nervous System
The Classification of Microgliomatosis with Particular Reference to Diffuse Microgliomatosis
Patterns of Proliferation in Cerebral Lymphoreticular Tumours
"Malignant Lymphoma" of the Brain Following Renal Transplantation
Human and Experimental Reticulum Cell Sarcoma (Microglioma) of the Nervous System
A Comparison of theFine Structure of Malignant Lymphoma and Other Neoplasms in the Brain
Fine Structure of Primary Reticulum Cell Sarcoma of the Brain
Ultrastructural Study of Two Central Nervous System Lymphomas
Primary Cerebral Reticulosis and Plasma Cell Differentiation
Nuclear Characteristics of Malignant Lymphoma in the Brain
The Ultrastructure of Reticulin
Certain Notable Clinical Attributes of the Histiocytic Sarcomas of the Central Nervous System
Differential Diagnostic Aspects in Malignant Lymphomas Involving the Central Nervous System
Cytology of the Cerebrospinal Fluid in Patients with Hodgkin's Disease or Malignant Lymphoma
Light- and Electronmicro-scopic Studies in Hemoblastosis with CNS-Disorder
Electron Microscopy of Lymphocytic Leukaemia Cells in the Cerebrospinal Fluid
Family Studies in Cases with Malignant Lymphomas
Clinical and Pathological Studies in a Case of Reticulum Cell Sarcoma
Lymphoblastic Extramedullary Spinal Tumor During Remission of Acute Lymphoblastic Leukaemie
Radiotherapy of Malignant Lymphomas
Chemotherapy of Malignant Lymphomas
Immunotherapy of Malignant Disease in Man
Meningeal Localisation of Acute Leukaemias
Prevention of Meningeal Leukaemia and Relapses by Cranial Irradiation and Intrathecal MTX in Acute Lymphatic Leukaemia
Atypical Progressive Multifocal Leuko-encephalopathy with Plasma-Cell Infiltrates
Leukoencephalopathy Following Combines Therapy of Central Nervous System Leukemia and Lymphoma
Diffuse Reticulosis with Leukomalacia
Unusual Infections of the Nervous System in Malignant Lymphomas
SSPE-like Inclusion Body Disorder in Treated Childhood Leukemia
The Ultrastructure of Normal and Reactive Microglia
EM Findings on the Source of Reactive Microglia on the Mammalian Brain
ExperimentalStudies on Kinetics and Functions of Monuclear Phagozytes of the Central Nervous System
Origin of Brain Macrophages and the Nature of the So-Called Microglia
The Relationship Between Microglia and Brain Macrophages. Experimental Investigations
Conclusions.