This volume is the third in the series devoted to Antibiotics initiated by Springer Verlag in 1967. The first two volumes were devoted to the Mode of Action of Antibiotics and Biogenesis, respectively and were received graciously. During the intervening years these two works have been used often by research workers and students alike and have been quoted extensively. Although a number of other excellent treatises on antibiotics have appeared, the Springer series has set a standard for thoroughness and quality that meets the need of the scientific community. It is against this background that the present Editors set about the preparation of a third volume in the Series on Antibiotics. Since the appearance of Volume I, also dealing with Mechanism of Action, tremendous strides have been made in the depth and breadth of our knowledge of molecular biology, microbial chemistry and molecular pharmacology and of their direct application to studies on the mode of action of drugs. The field of molecular biology itself was in its relative infancy during the preceding decade and the unique role played by many anti biotics in the development of our understanding of nucleic acid synthesis and function and its relationship to protein synthesis and cell physiology has led rapidly to a very precise, understanding of how many of these same antibiotics inhibit susceptible cells.

Section I. Interference with Nucleic Acid Biosynthesis

Anthramycin
3?-Amino-3?-Deoxyadenosine
Bleomycin
Berenil: A Trypanocide with Selective Activity against Extranuclear DNA
Camptothecin
Chloroquine (Resochin)
Distamycin A and Netropsin
Daunomycin (Daunorubicin) and Adriamycin and Structural Analogues: Biological Activity and Mechanism of Action
Edeines
Ethidium and Propidium
Kanchanomycin
Nalidixic Acid - Mode of Action
Olivomycin, Chromomycin, and Mithramycin
Quinacrine and Other Acridines
Quinoxaline Antibiotics
Rifamycins and Other Ansamycins
Sibiromycin
Thiaxanthenones: Miracil D and Hycanthone
Addendum
Trimethoprim and Pyrimethamine
Section II. Interference with Protein Biosynthesis
Althiomycin
Aurintricarboxylic Acid. A Non-Antibiotic Organic Molecule that Inhibits Protein Synthesis
Aminoglycoside Antibiotics
Borrelidin
Chloramphenicol
The Erythromycins
Emetine and Related Alkaloids
Fusidic Acid
Gougerotin
The Macrolide Antibiotics
Micrococcin and Micrococcin
Mikamycin
Pactamycin
Primaquine
The Streptogramin Family of Antibiotics
Streptomycin, Dihydrostreptomycin, and the Gentamicins
The Thiostrepton Group of Antibiotics
Section III. Interference with Cell Wall/Membrane Biosynthesis, Specific Enzyme Systems and Those in Which Mode of Action Not Known with Certainty
Berberine
Boromycin
Colicins 1972
Griseofulvin
Irehdiamine and Malouetine
Isonicotinic Acid Hydrazide
Sideromycins
Sulfonamides and Sulfones
Suramin
Vancomycin.