This supplement presents the papers submitted at the 27th meeting of the European Society of Toxicology, which was organised by the British Toxicology Society and held in Harrogate, England. As evident from the title of this book, the overall theme of the meeting was an exploration of some of the mechanisms of toxicity, as well as some models used in the investigation of toxic action. The topics dealt with can be grouped under four headings. The first of these, on the mechanisms involved in cell injury, was a joint symposium of the European Society of Toxicology and the Society of Toxicology of the United States of America. In the second group, mechanisms in carcinogen risk assessment were discussed. Mechanisms and models of teratogenesis was the subject of the third group of invited papers. Finally, a workshop on safety evaluation of biotechnological products dealt with present and future problems which this new area of technology poses for toxicologists. Short communications on recent studies and developments in toxicological techniques which were presented at the meeting are also included in this volume.

Mechanisms of Cell Injury

Mechanisms in Cancer Risk Assessment
Mechanisms and Models of Teratogenesis
Safety Evaluation of Biotechnology Products
Recent Studies and Technique Developments in Toxicology
Abstracts
Depletion of Hepatic Glutathione in The Guinea-Pig after Administration of (±)-Buthionine Sulphoxime
The Acute Effect of Buthione Sulphoxime on the Glutathione Content of Mouse Liver
How Much Can Arsenate Compete with Phosphate in Living Cells?
Effect of Exposure Time on the In Vitro Teratogenicity of Retinoic Acid
The Effect of Organic Solvents on Human Erythrocyte Membrane Adenosine Triphosphatase Activities In Vitro
The Perchlorate Discharge Test for Examining Thyroid Function in Rats
Pathological Changes in the Liver BALB/c Mice Induced by N-Methylformamide
The Effect of 1,3-Dinitrobenzene and Mono-(2-Ethylhexyl) phthalate on Lactate and Pyruvate Production by Rat Sertoli Cell Cultures
Toxicity of the Potential Antineoplastic Agent Ambazone
Reproduction Study of Rifaximin (L/105) In Rats
An Aid to the Maintenance of Disease-Free Animals
Author Index.