Mechanisms of Transcription presents a unique perspective on the fundamental processes of transcription. A collection of distinguished authors draws together the underlying mechanisms involved in the process of transcription. This includes RNA polymerase function and its interaction with promoter sequences, and the structures of the various components on the transcriptional machinery. Both prokaryotic and eukaryotic systems, NMR and crystallographic structures of a number of important eukaryotic transcription factors are discussed, as well as the role of chromatin structure.

Fundamental Aspects of T7 RNA Polymerase Structure and Mechanism

Transcription by T7 RNA Polymerase
Pribnow Box Recognition and Melting by Escherichia coli RNA Polymerase
Extended -10 Promoters
Promoter Selectivity Control of RNA Polymerase
The Effect of High Pressure on Transcription and on the Structure and Activity of E. coli RNA Polymerase
Ribosomal RNA Promoter-RNA Polymerase Interactions and rRNA Transcription in Escherichia coli
Synergistic Activation of Transcription in E. coli
Indirect Effects of DNA Sequence on Transcriptional Activation by Prokaryotic DNA Binding Proteins
Transcriptional Activation by a Topologically Linkable Protein: Forging a Connection Between Replication and Gene Activity
Translocation of DNA-Dependent E. coli RNA Polymerase During RNA Synthesis
Stabilisation of DNA Microloops by FIS - A Mechanism for Torsional Transmission in Transcription Activation and DNA Inversion
Transcription and DNA Topology in Eubacteria
Modeling Large DNA Molecules: Long-Range Interactions and Regulation of Transcription
Structure of the POU Domain
Structural Studies of Eukaryotic Transcription Initiation
Understanding SRY-Related 46X,Y Sex Reversal at the Atomic Level
Nucleosomes and Transcription
Antirepression, Potentiation and Activation of Promoters in Reconstituted Chromatin
Acetylation, Activation and Toxicity; the Role of ADA/GCN5 Complex in Transcription.