Osteonecrosis of the jaws is a well-known side-effect of antiresorptive therapy that predominantly occurs in patients suffering from malignant diseases and receiving intravenous administrations of nitrogen-containing bisphosphonates or subcutaneous administrations of denosumab, a monoclonal antibody. Less frequently it may also be observed in patients with osteoporosis who are being treated with these antiresorptive drugs

This textbook provides detailed, up-to-date information on all aspects of medication-related osteonecrosis of the jaws, including clinical features, pathogenesis, treatment options, and preventive measures. It also explains safe prevention and treatment strategies for patients receiving antiresorptive drugs who require extractions, implant insertions, and other dento-alveolar surgeries. This book will be of major interest for medical and dental students, dentists, and oral and maxillofacial surgeons as well as osteologists and oncologists.

Pharmacology of Antiresorptive Drugs

The Role of Antiresorptive Drugs in the Treatment of Osteoporosis
The Role of Antiresorptive Drugs in the Treatment of Skeletal Manifestations of Malignant Diseases
Clinical Features, Localization, Definition and Staging of the Disease
Radiological Findings / Imaging
General Characteristics and Risk Factors for BRONJ
Epidemiology
Histopathology of BRONJ
Prevention of Osteonecrosis and Dentoalveolar Surgery Under Treatment With Antiresorptive Drugs
Bisphosphonates and Dental Implants
Treatment of BRONJ
Local and Microvascular Flaps in ONJ-Treatment
Rehabilitation of Patients After BRONJ
Adjuvant Treatment Strategies
Microbiology and Antibiotics
Animal Models of ONJ
ONJ Under Denosumab and Other New Drugs
Possible Use of Antiresorptive Drugs in OMS
Dental Treatment Under BPs and After BRONJ
Dental Rehabilitation Under Bisphosphonates and After BRONJ
History of ONJ.