Membrane Trafficking in Viral Replication
The ability of viruses to exploit cellular functions for their own ends makes them highly effective pathogens and exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. Each of the eight chapters in this volume deals with a specific aspect of viral interactions with cellular membranes. These include chapters on viral entry, viral membrane fusion, viral membrane protein synthesis and transport, viral replication, viral interactions with cytoskeletal systems and the nucleus, the trafficking of viral membrane proteins and viral perturbation of host cell protein trafficking. These chapters should provide both an overview of cellular membrane trafficking mechanisms and viral interactions with these systems, as well as reviews of the current state of each of the fields. This CTMI volume deals with specific aspects of viral interactions with cellular membranes and includes chapters on viral entry, viral membrane fusion, viral membrane protein synthesis and transport, viral replication, viral interactions with cytoskeletal systems and the nucleus, the trafficking of viral membrane proteins and viral perturbation of host cell protein trafficking. The chapters provide overviews of viral interactions with cellular membrane trafficking mechanisms and up to date reviews of each field.
1;Preface;5 2;List of Contents;7 3;List of Contributors;8 4;Viral Entry;9 4.1;1 Introduction;10 4.2;2 Virus Receptor Binding;12 4.3;3 Virus Internalization;16 4.4;4 Postinternalization Trafficking;21 4.5;5 Membrane Penetration;22 4.6;6 Virus Uncoating;23 4.7;7 Virus Entry as a Target for Antiviral Drugs;24 4.8;8 Perspectives;26 4.9;References;27 5;The Many Mechanisms of Viral Membrane Fusion Proteins;33 5.1;1 Introduction;34 5.2;2 Activation of Viral Fusion Proteins;35 5.3;3 Classification of Fusion Proteins Based on Structural Criteria;38 5.4;4 Examples of Fusion Activation Mechanisms;40 5.5;5 Membrane Dynamics During Fusion;48 5.6;6 Membrane-Interacting Regions of Viral Fusion Proteins;49 5.7;7 Rafts in Viral Membrane Fusion;56 5.8;8 Inhibitors of Viral Fusion;57 5.9;9 Perspectives;59 5.10;References;61 6;The Role of the Cytoskeleton During Viral Infection;75 6.1;1 Introduction;76 6.2;2 The Cytoskeleton;78 6.3;3 Molecular Motors;82 6.4;4 Experimental Approaches;86 6.5;5 Neurotropic Herpesvirus and Cytoplasmic Transport;90 6.6;6 Retrovirus Entry and Budding;96 6.7;7 Adenovirus Entry and Microtubules;98 6.8;8 Parvovirus Entry and Microtubules;99 6.9;9 Poxviruses-Multiple Cargos for Microtubules and Actin Tails;100 6.10;10 Actin Remodelling During Baculovirus Infection;102 6.11;11 Perspectives;103 6.12;References;104 7;Nuclear Import in Viral Infections;117 7.1;1 Introduction;118 7.2;2 Nuclear Pore Complexes, Guardians of the Nucleus;119 7.3;3 Soluble Import Receptors Control Nuclear Access;121 7.4;4 Models of Nuclear Pore Complex Translocation;122 7.5;5 Ran-Independent Transport;124 7.6;6 Nuclear Import of Viral Genomes;125 7.7;7 Perspectives;136 7.8;References;137 8;Viral RNA Replication in Association with Cellular Membranes;147 8.1;1 Introduction;148 8.2;2 Alphaviruses as Models;149 8.3;3 Alphavirus-Like Superfamily;158 8.4;4 Picornavirus-Like Superfamily;162 8.5;5 Flavivirus-Like Superfamily;167 8.6;6 Nidoviruses;170 8.7;7 Concluding Remarks;171 8.8;References;175 9;Synthesis and Quality Control of Viral Membrane Proteins;183 9.1;1 Introduction;184 9.2;2 Protein Biosynthesis;184 9.3;3 Quality Control;193 9.4;4 How Viruses Evolve to Fool the Host;196 9.5;5 Conclusions;199 9.6;References;199 10;Receptor Modulation in Viral replication: HIV, HSV, HHV- 8 and HPV: Same Goal, Different Techniques to Interfere with MHC- I Antigen Presentation;207 10.1;1 Introduction;208 10.2;2 Receptor Modulation During Viral Replication: Interference with MHC- I Antigen Presentation;209 10.3;3 Perspectives;219 10.4;References;220 11;Trafficking of Viral Membrane Proteins;227 11.1;1 Introduction;227 11.2;2 The Cellular Protein Sorting and Trafficking Machinery;229 11.3;3 Traffic of Viral Envelope Proteins;235 11.4;4 Virus Assembly;248 11.5;5 Conclusions;251 11.6;References;252 12;Subject Index;263
Marsh, Mark
| ISBN | 9783540267645 |
|---|---|
| Artikelnummer | 9783540267645 |
| Medientyp | E-Book - PDF |
| Auflage | 2. Aufl. |
| Copyrightjahr | 2005 |
| Verlag | Springer-Verlag |
| Umfang | 259 Seiten |
| Sprache | Englisch |
| Kopierschutz | Digitales Wasserzeichen |
