1;Preface;5 2;List of Contents;7 3;List of Contributors;8 4;Viral Entry;9 4.1;1 Introduction;10 4.2;2 Virus Receptor Binding;12 4.3;3 Virus Internalization;16 4.4;4 Postinternalization Trafficking;21 4.5;5 Membrane Penetration;22 4.6;6 Virus Uncoating;23 4.7;7 Virus Entry as a Target for Antiviral Drugs;24 4.8;8 Perspectives;26 4.9;References;27 5;The Many Mechanisms of Viral Membrane Fusion Proteins;33 5.1;1 Introduction;34 5.2;2 Activation of Viral Fusion Proteins;35 5.3;3 Classification of Fusion Proteins Based on Structural Criteria;38 5.4;4 Examples of Fusion Activation Mechanisms;40 5.5;5 Membrane Dynamics During Fusion;48 5.6;6 Membrane-Interacting Regions of Viral Fusion Proteins;49 5.7;7 Rafts in Viral Membrane Fusion;56 5.8;8 Inhibitors of Viral Fusion;57 5.9;9 Perspectives;59 5.10;References;61 6;The Role of the Cytoskeleton During Viral Infection;75 6.1;1 Introduction;76 6.2;2 The Cytoskeleton;78 6.3;3 Molecular Motors;82 6.4;4 Experimental Approaches;86 6.5;5 Neurotropic Herpesvirus and Cytoplasmic Transport;90 6.6;6 Retrovirus Entry and Budding;96 6.7;7 Adenovirus Entry and Microtubules;98 6.8;8 Parvovirus Entry and Microtubules;99 6.9;9 Poxviruses-Multiple Cargos for Microtubules and Actin Tails;100 6.10;10 Actin Remodelling During Baculovirus Infection;102 6.11;11 Perspectives;103 6.12;References;104 7;Nuclear Import in Viral Infections;117 7.1;1 Introduction;118 7.2;2 Nuclear Pore Complexes, Guardians of the Nucleus;119 7.3;3 Soluble Import Receptors Control Nuclear Access;121 7.4;4 Models of Nuclear Pore Complex Translocation;122 7.5;5 Ran-Independent Transport;124 7.6;6 Nuclear Import of Viral Genomes;125 7.7;7 Perspectives;136 7.8;References;137 8;Viral RNA Replication in Association with Cellular Membranes;147 8.1;1 Introduction;148 8.2;2 Alphaviruses as Models;149 8.3;3 Alphavirus-Like Superfamily;158 8.4;4 Picornavirus-Like Superfamily;162 8.5;5 Flavivirus-Like Superfamily;167 8.6;6 Nidoviruses;170 8.7;7 Concluding Remarks;171 8.8;References;175 9;Synthesis and Quality Control of Viral Membrane Proteins;183 9.1;1 Introduction;184 9.2;2 Protein Biosynthesis;184 9.3;3 Quality Control;193 9.4;4 How Viruses Evolve to Fool the Host;196 9.5;5 Conclusions;199 9.6;References;199 10;Receptor Modulation in Viral replication: HIV, HSV, HHV- 8 and HPV: Same Goal, Different Techniques to Interfere with MHC- I Antigen Presentation;207 10.1;1 Introduction;208 10.2;2 Receptor Modulation During Viral Replication: Interference with MHC- I Antigen Presentation;209 10.3;3 Perspectives;219 10.4;References;220 11;Trafficking of Viral Membrane Proteins;227 11.1;1 Introduction;227 11.2;2 The Cellular Protein Sorting and Trafficking Machinery;229 11.3;3 Traffic of Viral Envelope Proteins;235 11.4;4 Virus Assembly;248 11.5;5 Conclusions;251 11.6;References;252 12;Subject Index;263