In nearly all parts of the world, the consumption of alcohol is increasing, and the morbidity and mortality of diseases induced by alcohol are rising correspondingly. It has been stated that alcohol is consumed because it pro duces intoxication. This effect is due to its toxicological influence on the central nervous system with the resulting functional disturbances. For many years, the concept that alcoholic liver disease was of nutritional origin and only indirectly related to alcohol consumption and metabolism was accepted. Opinion has changed gradually in recent years and tends now to regard alcohol itself through its combustion, as responsible for many metabolic disorders. Interest in this problem has increased during the past decade, and numerous papers bearing on this subject have appeared. It seems that the oxidation of alcohol in the liver interferes in many ways with the intermediary metabolism of lipids, carbohydrates and proteins, including enzymes and hormones, and exerts damaging influence on the liver, the musculature, the heart, the brain and the kidneys. The "Workshop Symposium" brought together a limited number of the scientists involved in the new development, biochemists, physiologists, pharmacologists, pathologists and clinicians from eight European countries and from the United States and allowed a very lively and informal exchange. The symposium was honored by the presence of Sir Hans Krebs, whose vast experience stimulated the discussion. It is a great pleasure to dedicate this volume to Sir Hans on the occasion of his 70th birthday on August 25th.

Metabolism of Alcohol and Alcohol Dehydrogenase

1) The Development of Alcohol Dehydrogenase and its Isoenzymes
2) Heterogeneity and Polymorphism of Human Liver Alcohol Dehydrogenase
3) Extrahepatic Oxidation of Alcohol and Alcohol Metabolites
4) Influence of Ethanol and Protein Deficiency on the Activity of Alcohol Dehydrogenase in Rat Liver
5) Ethanol Metabolism in Cirrhosis of the Liver
6) Studies on the Inhibitory Effect on Ethanol Oxidation in Man after Administration of 4-methylpyrazole
7) Ethanol Metabolism of the Isolated Perfuced Rat Liver. 1. Effect of Ethanol Oxidation on Substrate Levels. 2. Effects of Fructose and Pyrazole on Ethanol Oxidation
8) Experimental Hepatocellular Necrosis Induced by Ethanol after Partial Inhibition of Liver Alcohol Dehydrogenase
Ethanol Induced Ultrastructural Alterations in the Liver
9) Correlation of Biochemical and Functional Hepatic Changes with Ethanol Induced Ultrastructural Alterations
10) Ultrastructural and Cytochemical Studies of Alcoholic Hyalin and Megamitochondria
Effect of Ethanol on Microsomal Functions
11)Effect of Ethanol on the Activity of Microsomal Enzymes
12) Microsomal Oxidation of Ethanol and the Drug Metabolizing System. Studies in Animals and Man
13) Interaction between Ethanol Oxidation and Drug Metabolism
Effect of Ethanol on Metabolites and Coenzymes of the Energy Producing Metabolism
14) Ethanol as an Energy Producing Substrate in the Liver
15) The Influence of Ethanol on Metabolites and Coenzymes of the Energy producing Metabolism in Liver and Brain
16) Influence of Ethanol on the Metabolism of the Protein-deficient Fatty Liver
17) On the Independence of the Ethanol-Induced Triglyceride Accumulation in the Liver from Metabolic Changes Due to the Oxidation of Ethanol in the Liver
18) Ethanol Metabolism in Man, Studied by Liver Vein Catheterization (Effect of Ethanol on Glycerol Metabolism)
Effects of Ethanol on Carbohydrate Metabolism
19) Effects of Ethanol on Gluconeogenesis
20) The Effect of Alcohol on the Embden-Meyerhof-Parnas-Pathway in the Liver
21)Effect of Ethanol Oxidation on Gluconeogenesis from Alanine
22) Some Effects of Ethanol on Gluconeogenesis, Glycogenesis and Glycogenolysis
Effect of Ethanol on Hormone Metabolism
23) Effect of Ethanol on Steroid Metabolism
24) Ethanol and Cortisol Release in Man
25) The Influence of Antilipolytic Agents (Kö 592 and ß-Pyridylcarbinol) on Alcohol-Induced Deposition of Fat in the Liver
26) Origin and Pathogenesis of Fatty Acid Accumulation in the Liver During Prolonged Ethanol Consumption.