This volume opens by providing a comprehensive overview of the use and regulation of metals in our society, metal properties, and available testing methodologies. Common and uncommon metal allergens and sources of exposure are then reviewed in depth, detailing allergic responses and paying special consideration to select patient populations. In the general population, the prevalence of metal allergy is high. Environmental sources of metal exposure include jewelry, clothing, electronic devices, coins, leather, diet, and occupational exposure. Metal allergy may result in allergic contact dermatitis and systemic contact dermatitis, as well as several less common manifestations. Further, metal allergy has been associated with device failure and/or dermatitis following implantation of medical devices and dental implants. As metals are ubiquitous, this book will be indispensable for a wide range of clinicians and investigators. This handy reference will meet the needs of all health professionals and investigators who are interested in metal allergy and its diagnosis and management. 

Preface

I Metal: Overview
1 Use of metals in our society
2 Methods to detect metal composition: XRF, SEM, ICP-MS
3 Metal corrosion
4 EN1811
5 EN ISO 17075
6 Regulation of metal exposure to prevent allergy
II Metals, skin and the immune system
7 Deposition of metals on the skin and spot tests
8 Penetration of metals through the skin barrier
9 Innate immune system response: Toll-like receptors
10 Acquired immunity: T cell response
11 Tolerance development
12 Metal patch testing.-13  Lymphocyte proliferation assays
III Allergens
14 Aluminum
15 Berylium
16 Chromium
17 Cobalt
18 Copper
 19 Gold
 20 Nickel
21 Palladium
22 Titanium
23 Other metals: iron, platinum, tin, zinc
 IV Common Sources of Metal Exposure
 24 Metals in every day devices
25 Metals in tools and the workplace
26 Metals in cosmetics
 27 Metals in coins
 28 Metals in the diet
 V Hypersensitivity to Metallic Implants
29Orthopedic Metal Implants
 30 Cardiovascular Metal Implants
31 Dental Metal Implants
32 Other Metal Implants: Gynecological, Neurovascular
33 Diagnostic work-up of patients with metal implant failure
 VI Metal Allergy in Select Patient Populations
34 Metal allergy in children
35 Metal allergy in atopic dermatitis
36 Metal allergy in Asia
 VII Uncommon Manifestations of Metal Allergy
37 Metal allergy in asthma
38 Metal allergy in palmoplantar pustulosis
39 Metal allergy in endometriosis
40 Systemic Nickel Allergy Syndrome
Future research areas
Subject Index.