This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Part I: Pharmacological bases of metronomic chemotherapy: The metronomic concept

Antiangiogenic effects of metronomic chemotherapy
Effects of metronomic chemotherapy on immunity
Other proposed mechanism of action of metronomic chemotherapy. Part II: Preclinical studies of metronomic chemotherapy: Alkylating agents
Camptothecins
Fluoropyrimidines
Taxanes
Vinca alkaloids
Anthracyclines
Other drugs
Part III. Drugs combined with metronomic chemotherapy in preclinical studies: Tyrosine kinase inhibitors
Monoclonal antibodies
Tumor vaccines
Other drugs. Part IV. Clinical activity of metronomic chemotherapy: Breast cancers
Prostate cancers
Gastrointestinal cancers
CNS cancers
Pediatric malignancies
Sarcomas
Hematological cancers
Liver cancers
Gynecologic Cancers
Lung cancers
Other cancers. Part V: Clinical Pharmacology of metronomic chemotherapy: Pharmacokinetics of metronomic chemotherapy
Pharmacodynamics of metronomic chemotherapy
Pharmacogenetics of metronomic chemotherapy
Pharmacoeconomics of metronomic chemotherapy and its social impact
Adverse drug reactions of metronomic chemotherapy. Part VI: Metronomic chemotherapy in veterinarian clinic: Clinical studies of metronomic chemotherapy alone
Clinical studies of metronomic chemotherapy and other drugs.