Modeling Fragile X Syndrome

Modeling Fragile X Syndrome

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Introduction.-Probing Astrocyte Function in Fragile X Syndrome.- Neural Stem Cells.- Fragile X Mental Retardation Protein (FMRP) and the Spinal Sensory System.- The Role of the Postsynaptic Density in the Pathology of the Fragile X Syndrome.- Behavior in a Drosophila model of Fragile X.- Molecular and Genetic Analysis of the Drosophila Model of Fragile X Syndrome.- Fragile X Mental Retardation Protein and Stem Cells.- Manipulating the Fragile X Mental Retardation Proteins in the Frog.- Exploring the Zebra finch Taeniopygia gutta as a Novel Animal Model for the Speech-language Deficit of Fragile X Syndrome.- Neuroendocrine Alterations in the Fragile X Mouse.- Taking STEPs forward to understanding Fragile X Syndrome.- Fmr-1 as an Offspring Genetic and a Maternal Environmental Factor in Neurodevelopmental Disease.- Mouse Models of the Fragile X Premutation and the Fragile X Associated Tremor/Ataxia Syndrome.- Clinical Aspects of the Fragile X Syndrome.- Fragile X Syndrome: A Psychiatric Perspective.- Fragile X Syndrome and Targeted Treatment Trials.- The Fragile X-associate Tremor Ataxia Syndrome.- Vignettes: Models in Absentia.

Introduction: Reminiscing on Models and Modeling
Probing Astrocyte Function in Fragile X Syndrome
Neural Stem Cells
Fragile X Mental Retardation Protein (FMRP) and the Spinal Sensory System
The role of the postsynaptic density in the pathology of the fragile X syndrome
Behavior in a Drosophila model of Fragile X
Molecular and Genetic Analysis of the Drosophila Model of Fragile X Syndrome
Fragile X Mental Retardation Protein and Stem Cells
Manipulating the Fragile Mental Retardation Proteins in the frog
Exploring the zebra finch Taeniopygia guttata as a novel animal model for the speech-language deficit of fragile X syndrome
Neuroendocrine alterations in the fragile X mouse
Taking STEPs forward to understanding Fragile X Syndrome
Fmr-1 as an offspring genetic and a maternal environmental factor in neurodevelopmental disease
Mouse Models of the Fragile X Premutation and the Fragile X Associated Tremor/Ataxia Syndrome
Clinical Aspects of the Fragile X Syndrome
Fragile X Syndrome: A Psychiatric Perspective
Fragile X Syndrome and Targeted Treatment Trials
The Fragile X-associated Tremor Ataxia Syndrome
Vignettes: Models in Absentia.

ISBN 978-3-642-27010-9
Artikelnummer 9783642270109
Medientyp Buch
Auflage 2012
Copyrightjahr 2013
Verlag Springer, Berlin
Umfang XII, 392 Seiten
Abbildungen XII, 392 p.
Sprache Englisch