This volume provides a comprehensive account of the mostrecent trends in human leukemia, as presented at the NinthWilsede Meeting. The internationally renowned contributorsdeal with all different aspects of these diseases: As wellas discussing important clinical aspects of leukemia, newinformation on the biological basis of leukemia gained usingthe methods of molecular genetics, cell and molecularbiology, virology, and immunology is covered. The book showsboth the complexity of leukemia research, as well as thevalue of basic scientific research in furthering clinicalmedicine and therapy.

Clinical Aspects

Bone Marrow Transplantation in Children with Acute Leukemia: A 1990 View
Proliferation-Including Effects of Recombinant Human Interleukin-7 and Interleukin-3 in B-Lineage Acute Lymphoblastic Leukemia
Effects of Granulocyte Colony-Stimulating Factor in Children with Severe Congenital Neutropenia
Interleukin-1 Production in Patients with Nonlymphocytic Leukemia and Myelodysplastic Syndromes
The Results of Treatment of Acute Lymphoblastic Leukemia Relapses in the Polish Children's Leukemia/Lymphoma Study Group
Long-Term Follow-up Study in Childhood Acute Lymphoblastic Leukemias
Monoclonal Blast Cell Proliferation in Transient Myeloproliferative Disorder
The Comparison of the Expression of Activation Antigens on Peripheral Blood Mononuclear Cells in Chronic Lymphocytic Leukemia and in Hairy Cell Leukemia
Multiple Myeloma: Immunodeficient, Osteolytic, Renal, and Amyloid Syndromes
Prognostic Factors in Patients with Multiple Myeloma
Cytogenetic Disorders During Tumor Progression in Leukemia
New Cytogenetic Aspects of Myelodysplasia and Acute Leukemia
Detection of Minimal Residual Leukemia by Polymerase Chain Reactions
Structural Changes in Blast Cell Chromatin and DNA in Patients with Acute Leukemia After Cytosar and Irradiation Treatment
Cell Biology
Animal Models of Normal and Leukemic Human Hematopoiesis
Colony Stimulating Factors: Regulation of Production
Adhesive Interactions in the Regulation of Haemopoiesis
In Vitro Effect of GM-CSF and IFN-? on the Establishment of Stromal Layer and Hemopoiesis in Human Dexter Culture
The Effect of Bone Marrow Fibroblast and Stromal Cell-Conditioned Media on Hemopoietic Cells in Culture
Hemopoietic Stem Cells in Embryogenesis of the Mouse
Induction of Differentiation ofthe Human Promyelocytic Cell Line (HL-60) by Conditioned Medium of Ceathea letifera-Stimulated Mononuclear Cells
Molecular Mechanisms in Myeloid Lineage Development
Proteoglycans in Cellular Recognition and Secretory Functions in the Haemopoietic System
Modification of the In Vitro Replication of the Human Immunodeficiency Virus HIV-1 by TPSg, a Polysaccharide Fraction Isolated from the Cupressaceae Thuja occidentalis L. (Arborvitae)
Molecular Genetics
Molecular Cloning and Expression of CD 34: A Haemopoietic Progenitor-Associated Cell Surface Glycoprotein
Molecular Genetics of the Human GM-CSF Receptor
Structural Organization of the Cytokine Gene Cluster on Human Chromosome 5
Genes Encoding Tumor Necrosis Factors: Genome Organization, Polymorphism, and Expression
Molecular Characterization of the Mouse Interleukin-3 Receptor
Signal Transduction Through Foreign Growth Factor Receptors and Oncogenes Transfected into Interleukin-3-Dependent Hematopoietic Cells
Genetic Analysis of Ion Transport
Virology
The Molecular Biology of the Myeloproliferative Leukemia Virus
Raf Function is Required for Proliferation of NIH/3T3 Cells and Transformation by Nonnuclear Oncogenes
erbB*a: an "Ignition Spark" for the Xiphorus Melanoma Machinery?
Analysis of Human Retroviral Regulatory Proteins Tax and Tat
Human Neuroblastoma: Paradigm for a Tumor with Oncogene Amplification and Loss of a Putative Tumor Suppressor Gene
Activation of Gene Expression by Human Herpes Virus 6
Expression of S71-Related Sequences in Human Cells
Selective Integration of Rous Sarcoma Virus Genome in High- and Low-Metastatic Transformed Cell Lines
Molecular Mechanism of Alteration of H-ras I Oncogene in Human Breast Carcinomas: G to T Transversion in 12th Codon of theUndeleted Allele in the Case of the Loss of the Other Gene Allele
Immunology
Natural Killer Cell Mediated Defence Directed Selectively Against Target Cells Lacking MHC Class I Gene Products
Tumor Rejection Antigens and Immune Surveillance
Glycophosphatidylinositol-Anchored Membrane Proteins as Coreceptors in T-Cell Activation
The Molecular Mechanism of Muramyl Peptides' Biological Activity
A Novel Nuclear Factor Binds to the NF-KB Motif in the Interleukin-2 Enhancer
Soluble Cytokine Receptors as Immunomodulators
Early Life and Evolution
Immunological Self-Nonself Discrimination and Numerous Peptide Fragments Shared by Unrelated Proteins
Multigene Families: The Problem of Molecular Recapitulation
Repeated Intragenome "Parasites" as a Factor in Molecular Coevolution
Frozen Temporal Pattern in Growing Systems
On Some Concepts in Modeling Nonlinear Phenomena.