Presented here are recent advances in biochemical, toxicological, and regulatory aspects of oxidative drug metabolizing enzymes. Mainly cytochrome P450-dependent and flavin-containing monooxygenases (FMO) are covered. Moreover, the book deals with genotoxicity studies and toxicological interactions of environmental chemicals and mechanisms of mutagenicity and tumor formation. The construction of genetically engineered mammalian cells for the production of a specific P450 isozyme and the application of these cell lines in drug metabolism, mutagenicity and toxicity studies are described in detail. Further, insight is provided into how a number of aquatic species cope with pollutants and their genotoxicity.

to Cytochrome P450

General Aspects of NADPH Cytochrome P450 Reductase and Cytochrome b5
Interaction Between Cytochrome P450 and Reductase
Molecular Biology of Cytochrome P450: Evolution, Structure and Regulation
The Role of Nuclear Receptors in the Regulation of P450s and Other Genes by Peroxisome Proliferators
Mapping Determinants of the Substrate Specificities of P450s by Site-Directed Mutagenesis
Diversity and Regulation of Cytochromes P450 in Aquatic Species
Cytochrome P450 Expression in Rainbow Trout: An Overview
Molecular Aspects of Cytochrome P450 2E1 and Its Roles in Chemical Toxicity
Problems Associated with Assessment of the Contribution of Individual Forms of Cytochrome P450 to the Metabolism of Xenobiotics
Emergence of the Flavin-Containing Monooxygenase Gene Family: Molecular Biology, Structure, and Function
Flavin-Containing Monooxygenases: Substrate Specificity and Complex Metabolic Pathways
Developmental Regulation of Biotransformation of Drugs and Other Xenobiotics
Modulation of Xenobiotic Metabolism and Toxicity by Dietary Chemical
Mechanisms of Mutagenicity and Tumour Formation
Genotoxicity Assays
Use of Mechanistic Information for Adequate Metabolic Design of Genotoxicity Studies and Toxicological Interactions of Drugs and Environmental Chemicals
Significance of Posttranslational Modification of Drug Metabolizing Enzymes by Phosphorylation for the Control of Carcinogenic Metabolites
The Construction of Cell Cultures Genetically Engineered for Metabolic Competence towards Xenobiotics
In Vitro Systems as Analytical Tools for Understanding and Predicting Drug Metabolism In Vivo
The Role of Oxidative Enzymes in the Metabolism and Toxicity of Pesticides
Metabolism of Xenobiotic Proestrogens and Estrogens by Cytochrome P450
Metabolism of Antiestrogenic Anti-Cancer Agents by Cytochrome P450 and Flavin-Containing Monooxygenases. Mechanism of Action Involving Metabolites
Therapeutic Agents and Cytochrome P450
Drug Metabolism, Lipid Peroxidation and Glutathione
Health Environment of Altai Territory and Monooxygenase and Conjugating Activities in Placentae of Newborn
Monooxygenase Measurements as Indicators of Pollution in the Field
Biochemical and Genotoxicological Monitoring of Ecosystems with Special Reference to Lake Baikal and Northern Black Sea
Relating Biochemical Responses to "Higher Order" Effects
List of Invited Contributors.