Biological membranes are often effected by diseases. Molecular events leading to or arising from pathological changes in the course of different diseases are as yet not clearly understood. This competent study by leading experts covers changes of the cellular environment, membranes and the metabolic functions during tissue growth and differentiation as well as aspects of abnormal organelle function in lysosomal storage diseases, peroxisomal and mitochondrial disorders, enzyme defects and regulatory defects of receptors due to oncogenes.

1 Plasma Membrane and Control of Ceü Growth and Differentiation

Insulin Receptor Kinase and Insulin Action
Structural and Functional Aspects of Signal Transduction by Receptor Tyrosine Kinases
Nerve Growth Factor (NGF): Physiological Functions and Regulation of Its Synthesis
Signal Transduction by Growth Factor Receptors
Altered Regulation of Receptor-Associated Tyrosine Kinases in Human Tumors
The Role of Plasma Membrane Phospholipids in Cellular Pathology
Changes in the Structure and Function of the Red Cell Membrane Skeleton and Hemolytic Anemias
Regulation of Intracellular Ca2+ in Pancreatic Acinar Cells by Membrane Pumps and Channels
Control of Protein Kinase C Function by Activators and Inhibitors
2 Regulation of Membrane Channels
K+ Channels: Structure, Function, Regulation, Molecular Pharmacology and Role in Diseased States
Voltage-Dependent Calcium Channels: Structure and Regulation in Normal and Abnormal States
Cell Membrane Abnormalities in Genetic Hypertension
Transmembrane Cation Transport: An Approach to the Study of the Molecular Basis of Hypertension
Transmembrane Ionic Fluxes in the Brain in Energy-Depleted Cells
3 Mitochondrial Genetic Diseases
Mitochondrial Diseases
Mitochondrial Myopathy: Biochemical Approaches to Respiratory Chain-Linked Electron Transfer and Energy Coupling
Phosphorus Magnetic Resonance Spectroscopy (31P NMR) as a Tool for in Vivo Monitoring of Mitochondrial Muscle Disorders
Cytochemical and Immunocytochemical Studies of Human Mitochondrial Myopathies
Regulatory Complexity of Cytochrome c Oxidase and Its Defective Manifestation in Mitochondrial Diseases
Fibroblasts and Cytochrome c Oxidase Deficiency
Human Cytochrome c Oxidase Deficiencies; Structural and Functional Aspects
4Mitochondrial Metabolic Diseases
Brown Adipose Tissue, Diet-Induced Thermogenesis and Genetic Obesity
Acute and Long-Term Regulation of Brown Adipose Tissue Thermogenesis: Physiological and Pathological Implications
Molecular Composition, Fluidity of Membranes and Functional Properties of Human Liver Mitochondria and Microsomes
Changes in Erythrocyte and Platelet Membrane Fluidity in Childhood Obesity
Skeletal Muscle Mitochondria and Phospholipase Activity in Malignant Hyperthermia
The Antimitochondrial Antibodies (AMA) of Primary Biliary Cirrhosis (PBC)
Toxicity, Antioxidants, and Metabolism
5 Cancer and Energy Metabolism
Mitochondrial H+-ATP Synthase Under Normal and Pathological Conditions
Antitumor Effect of Drugs Interfering with Mitochondrial Biogenesis
6 Lysosomes and Peroxisomes in Health and Disease
The Complex of ²-Galactosidase, Neuraminidase and "Protective Protein" in Lysosomes: Molecular Characterization of the "Protective Protein"
The Role of Activator Proteins in Glycolipid Degradation and Storage Diseases
Solute Translocation Across the Lysosome Membrane: Physiology, Pathology and Pharmacology
The Peroxisomal ?-Oxidation Systems: Characteristics and (Dys) Functions in Man
Genetic Heterogeneity in Inherited Disorders with a Generalized Impairment of Peroxisomal Functions: Visualization by Immunofluorescence Microscopy of Peroxisome Assembly After Somatic Cell Fusion of Complementary Cell Lines.