The outstanding contributions to this volume are designed to shed light on some fields of cell biology and cellular pathology, including newly observed phenomena of cell-cell interactions, which might be applicable in studying the pathological process of atherosclerosis. The topics included cover: lipoproteins and lipoprotein receptors; growth factors; endocytosis and exocytosis; ONC Genes and proliferative disease; white blood cells; prostaglandins and leukotrienes; and the biology of smooth muscle and endothelium. The volume provides a complete summary of the most important developments in the field with great impact for arteriosclerosis research.

Workshop I Lipoproteins and Lipoprotein Receptors

LDL Receptor Mutations in Patients with Familial Hypercholesterolemia
Lipoprotein Receptors and Their Ligands: Structure and Function of Apoproteins E and B
The Role of HDL in Cholesterol Homeostasis of Macrophages and Reversed Cholesterol Transport
Lipoproteins, Macrophages and Atherosclerosis
Arterial Lipoprotein Metabolism: Site-Specific Differences Related to Susceptibility to Atherosclerotic Lesions
Lipoprotein Disposition by the Liver: A Concerted Action of Various Cell Types
The Macrophage and Endothelial Cell Scavenger Receptor
Characterization of the Hepatic Scavenger Receptor
Workshop II Growth Factors
The Role of PDGF in Health and Disease
Role of PDGF-like Growth Factors in Autocrine Stimulation of Cell Growth
The PDGF Receptor as a Mediator of Mitogenesis
Alpha-and Beta-Heparin Binding Growth Factors: Chemistry and Biology of Acidic and Basic Fibroblast Growth Factors
Structure, Homologies and Activities of Acidic Fibroblast Growth Factor
Endothelial Cell Growth Factor and its Receptor
Workshop Ill Endocytosis and Exocytosis
Intracellular Transport of Human Class I Antigens and an Adenoviral Glycoproteìn
Molecular Mechanisms of Endocytic Sorting
Characterisation of a Fusion Event from the Endocytic Pathway
Membrane Boundaries Involved in the Selective Trafficking of Cell Surface Receptors
The Molecular Basis of Human Cellular Iron Metabolism
Workshop IV ONC Genes and Proliferative Disease
Molecular Features Involved in Cell Surface Receptor Function and Their Role in Oncogenesis
Transforming Activity of the fms Oncogene (CSF-1 Receptor)
Functional and Structural Analysis of the v-src and c-src Genes
Ras Oncogenes and Cell Transformation
Cis RegulatoryControl of mos Oncogene Expression
Analysis of the Function of the fos Oncogene Product
Cooperative Interactions Involving Cellular and Viral Oncogenes in the Development of Malignant Tumors
Workshop V White Blood Cells
The Motor of Leukocytes and Platelets: 1986
Heterogeneity of Murine and Human Fc? Receptors
Complement Receptors
Cachectìn: A Macrophage Protein that Induces a Catabolic State in Infected Animals
The Role of Cytosolic Free Calcium, (Ca2+)i, and Phosphoinositides as Intracellular Signals
The Macrophage-Blood Interface: Cell Localisation and Recruitment in Bone Marrow, Liver and Brain
Normal and Neoplastic Early Lymphocyte Maturation
Molecular Regulation of Complement Gene Expression
Workshop VI Prostaglandins and Leukotrienes
The Role of GTP-Binding Proteins in Coupling Prostaglandin and Leukotriene Receptors to Intracellular Second Messenger Systems
Regulation of Vascular Tone by Prostaglandins and Endothelium-Derived Relaxing Factor
Endogenous Cysteinyl Leukotrienes as Mediators in Endotoxin Shock and Tissue Trauma
Source and Mechanism of Release of Arachidonic Acid in Blood Platelets
Eicosanoids and the Pulmonary Circulation
Regulation of the Production (Leukotriene A4 Hydrolase) and the Action (Leukotriene B4 Receptor Sites) of Leukotriene B4
Enzymic Synthesis and Degradation of Prostaglandin D2
Receptor-Dependent Regulation of Human Polymorphonuclear Leukocyte Responses to Leukotrienes
Leukotriene C4-Binding Proteins
Leukotriene C Metabolizing Enzymes
Workshop VII Biology of Smooth Muscle and Endothelium
The Fibrinolytic System of Cultured Bovine Aortic Endothelial Cells
Tumor Necrosis Factor/Cachectin and the Modulation of Endothelial Cell Coagulant Properties
Membrane Glycoproteins ofEndothelial Cells and Platelets
The Molecular Biology of Endothelial Cell von Willebrand Factor
Induction and Regulation of Endothelial Gene Expression
Endothelium-Vascular Smooth Muscle Interactions in Culture
Endothelial Morphogenesis
Closing Remarks
Final Word
List of Participants
List of Sponsors.