A small informal symposium on "Molecular Genetics" was organized by us on behalf of the "Gesellschaft Deutscher Naturforscher und Arzte" and took place in Berlin in October 1967. There were about 40 partici pants from Europe and the United States. Molecular Genetics represents today an extraordinarily comprehensive research field. Therefore the organizers of the symposium had the choice either of limiting the meeting to a particular topic or of covering a wider selection of current problems. The latter alternative was chosen. The fields of research of the participants covered the broad range of scientific problems in which molecular genetics is nowadays involved: Genetic code; chemistry and biosynthesis of proteins; mutation, modification and reactivation of nucleic acids; biochemistry of regulation; comple mentation; structure; replication and function of viruses, etc. The meeting took place in the Hotel Schweizerhof where the partici pants were also accommodated. This permitted close contact between the participants outside of the official program and allowed informal discussions, which started during the meetings, to be continued after wards. Owing to the informal nature of these discussions, only a part of them could be included in this book. Berlin, September 1968 H. G. WITTMANN H. SCHUSTER Contents List of Participants . . . . . . . . . . .... VII I. Structure and Function of Ribosomes; Complementation Complementation and Dominance Relationsship between Protein Subunits. By J. R. S. FINCHAM. . . . . . . . . . . . . . . Ribosomal Proteins of E. coli and Yeast. By E. KALTSCHMIDT, V. RUDLOFF, G. STOFFLER, A. CHERSI, M. DZIONARA, D. DOl\IIER, and H. G. WITTMANN . . . . . . . . . . . . . . .. . . 5 .

I. Structure and Function of Ribosomes; Complementation

Complementation and Dominance Relationsship between Protein Subunits
Ribosomal Proteins of E. coli and Yeast
Studies on Purified E. coli Ribosomal Proteins
Structural Studies on Ribosomal Proteins: Peptides from Cyanogen Promide Cleavage and Tryptic Digestion
The Role of 30 S Ribosomal Subunits in Initiation of Protein Synthesis
Structure and Function of Ribosomes: Studies on Dissociation and Reconstitution of Ribosomal Particles
The Formation of the Peptide Bond on Ribosomes
II. Codons; Protein Synthesis
Synthesis of Polyphenylalanine in a Cell-free System from E. coli A 19: Ribosomal Binding Sites, Initiation with Formyl-methionyl-tRNA, and Codon-Interaction of Aminoacyl-Trna
Modification of DNA-Dependent RNA-Polymerase in T 4 - infected E. coli
Genetic Control of Translation of Nonsense Triplets
The Recognition of Anomalous Triplet-Codons by Aminoacyl-tRNA
Structure and Cellular Function of Aminoacyl Ribonucleic Acid Synthetases
The Formation of Phenylalanyl-tRNA-synthetase Crossreacting Material in Temperature sensitive Mutants of E. coli
III. Modification, Reactivation, Mutation
Host-Controlled Modification of DNA
Genetic Recombination Induced by Ultraviolet Light
Repair of DNA in a Mutant of E. coli Temperature-Sensitive in DNA Synthesis
Prophage Attachment and Detachment: Comparison of Phages P 2 and ?
Mutants of Serratia Marcescens Defective or Superactive in the Release of a Nuclease
IV. Regulation
In vivo Studies of Inducer-Repressor Interactions
Strong-Polar Mutations in the Galactose Operon of E. coli
The Role of the Promoter Site in Gene Expression
Regulation of Pyruvate Dehydrogenase Synthesis: Substrate Induction
Transcription in Amino AcidStarved Bacteria
Hemoglobins of Chironomus tentans and C. pallidivitatus: Biochemical and Cytological Studies
V. Virus
Gene Functions and Genetics of Phage S 13
Distribution of Thymidilate Incorporation into the DNA of X 174-Infected Triphosphate Permeable Cells
Primary Structure of fd Coat Protein. Comparative Studies with Proteins of Phages fl, M 13 and ZJ-2
Control Mechanisms in T 4 Infection: Studies on the Exclusion of the RNA Phage M 12 in Mixedly Infected Cells
Defective Plant Viruses
Gene Functions of Influenza Virus.