Nuclear Medicine techniques have advanced to such a degree that biochemical transparency of the human body has reached the doorstep of medical application. The book gives background, techniques and examples in an interdisciplinary approach to quantify biochemical reactions in vivo by regional imaging and in vitro analyses. The goal is to assess in vivo biochemical homeostatic circuits under control by genes and protein interactions. It becomes apparent how nuclear medicine can aid clinical researchers and practitioners, human geneticists and pharmacologists in understanding (and affecting) gene-phenotype relationships operating in vivo and thus can help eventually to bring functional genomics and proteomics to clinical medicine.

 

I Primary Topics

1 Measurements of Biochemical Reactions in Vivo
2 The Human Genome and Disease
3 Functional Genomics and Proteomics: Basics, Opportunities and Challenges
4 How Proteins Speak with One Another in Cell Signaling
5 Labeled Agents as Tracers and Carriers: Theory and Practice
6 Instrumentation for Measuring Metabolism
7 Modelling Metabolite and Tracer Kinetics
8 Compound Delivery and Local Blood Flows
II Whole Body Processes
9 Endothelium and Compound Transfer
10 Coagulation and Peripheral Vascular Disease
11 Molecular Imaging of Infection and Inflammation
12 Element Metabolism and Body Composition
13 The Biology of Aging and Related Nuclear Medicine Studies
14 In Vitro Indicators of Metabolism of Natural Compounds
III Organ Systems
15 Endocrinology
16 Noninvasive Assessment of Inherited Cardiac Disease Using Positron Emission Tomography
17 Molecular Background of 18F-2-deoxy-D- glucose (FDG) Uptake in the Ischemic Heart
18 Imaging Studies in Substance Abuse
19 Imaging of Cerebral Metabolism in Huntington's Disease
20 Monoamine Oxidase: Radiotracer Development and Human Studies
21 Amino Acid Transport Studies in Brain Tumors
22 Lung
23 Functional Genomics and the Liver
24 Molecular Gastrointestinal Scintigraphy
25 The Kidney and Genital System
26 Biomolecular Magnification Imaging of Musculoskeletal Diseases
IV Tumors
27 Molecular Imaging in Oncology
28 Nuclear (PET/SPECT) Imaging of Gene Expression: Methods and Applications
29 Development of DNA-based Radiopharma- ceuticals Carrying Auger-Electron Emitters for Anti-gene Radiotherapy
V Special Topics
30 The Role of Nuclear Medicine in Relation to Alternative Modalities
31 MR Contrast Agents for Molecular and Cellular Imaging
32Magnetic and Optical Molecular Imaging. Live Cell and Tissue Fluorescence: Imaging Techniques and Methods
33 Biological Effects of Low Doses of Ionizing Radiation: Damage versus Protection.