The subject of this book is the physico-chemical theory of the origin of life. Although this theory is still in statu nascendi, it has been developed in recent years to the point where a coherent presentation is possible. The book is intended as an introductory text for students of physics, chemistry or biology. This interdisciplinary aim has necessitated a choice of material based on the lowest common denominator of physicists and biologists. In particular, the predominantly mathematical and biological sections have been presented at the most elementary l.evel possible. The less mathematically inclined reader can omit Sections (5.3)-(5.5), (5.7)-(5.10), (6.2), (6.3), (9.1)-(9.3), (12.1) and (13.3) without losing the overall view. For critical reading of the manuscript, for discussions and for many useful suggestions I wish to thank M. Eigen (Gottingen), w.e. Gardiner (Austin), D. Porschke (Gottingen), P. Schuster (Vienna), P.R. Wills (Auckland) and P. Woolley (Berlin). The translation of the original, German manuscript into English was kindly undertaken by Paul Woolley. During this and subsequent stages of revision he introduced a great many improvements in the text and the presentation of material. My particular thanks are due to him for his decisive contribution to this book. Last of all I wish to thank Ingeborg Lechten for typing the text in its various stages of evolution. The completion of this book is largely to be attributed to her patience and efficiency.

I. The Molecular Basis of Biological Information

1. Definition of Living Systems
2. Structure and Function of Biological Macromolecules
3. The Information Problem
II. Principles of Molecular Selection and Evolution
4. A Model System for Molecular Self-Organization
5. Deterministic Theory of Selection
6. Stochastic Theory of Selection
III. The Transition from the Non-Living to the Living
7. The Information Threshold
8. Self-Organization in Macromolecular Networks
9. Information-Integrating Mechanisms
10. The Origin of the Genetic Code
11. The Evolution of Hypercycles
IV. Model and Reality
12. Systems Under Idealized Boundary Conditions
13. Evolution in the Test-Tube
14. Conclusions: The Logic of the Origin of Life
Mathematical Appendices
A.1. The Eigenvalue Problem
A.2. Linear Stability Analysis
A.3. The Method of Lagrange Multipliers
A.4. Stochastic Processes.