Mosaicism is a powerful biologic concept, originally developed from studying plants and animals. All cutaneous neoplasms, both benign and malignant, reflect mosaicism, which is the necessary basis to explain numerous human skin disorders. For example, various mosaic patterns visualize the embryonic development of human skin and X-linked skin disorders explain why women live longer than men, and so on. This book presents, for the first time, a comprehensive overview on the strikingly manifold patterns and peculiarities of mosaic skin disorders. This reader-friendly structured and straightforward publication will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome.

PATTERNS AND MECHANISMS: Mosaicism as a Biological Concept:

History
Mosaicism in Plants, Animals, Humans
Mosaicism Versus Chimerism
The Mechanisms of Mosaicism
Genomic Mosaicism of Autosomes
Epigenetic Mosaicism of autosomes
Genomic Mosaicism of X Chromosomes
Epigenetic Mosaicism of X Chromosomes
The patterns of Mosaicism
Lines of Blaschko
Checkerboard Pattern
Phylloid Pattern
Patchy Pattern Without Midline Separation
Lateralization
Other Patterns, so far Unclassifiable
MOSAIC SKIN DISORDERS: Nevi
Melanocytic Nevi
Other Forms of Pigmentary Mosaicism
Epidermal Nevi
Vascular Nevi
Connective Tissue Nevi
Nevoid Skin Disorders
Lyonization (Functional X-Chromosome Mosaicism) in X-Linked Skin Disorders
Autosomal Non-Nevi
Neoplastic Skin Lesions
Benign Tumors
Malignant Tumors
CONCLUSION.